Inula helenium, Elecampane

Enulae Campane, Helenii

Inula racemosa

Rasan, Rasin (Unani)

Pushkar (Ayurveda)
Ma Nu  མ་ནུ  (Tibetan)
Tu Mu Xiang (TCM)

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Gart der Gesundheit, Cuba, 1485

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Herbarius latinus, Petri, 1485

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Ortus Sanitatis, Meydenbach, 1491

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Kurtzes Handtbuchlein, Ryff, 1599

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Inula helenium
Berg,, Atlas der officinellen Pflanzen (1891)

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ELECAMPANE ROOT
Notes on Pharmacognosy
By Otto Augustus Wall, 1902

Botanical name:

Inula spp.
Two main species are used:

  1. I. helenium (Europe)
  2. I. racemosa is used very similarly in Ayurveda and Tibetan Medicine (Pharmacographica Indica, Dymock, 1891)

Inula helenium and I. racemosa are listed as the source for Tu Mu Xiang (a variety of Costus Mu Xiang) in the Chinese Pharmacopoeia. In addition, the flower of the related Inula japonica Xuan Fu Hua is used in TCM

Parts used:

Root

Temperature & Taste:

Warm, dry. Sweet, a little Bitter and Pungent
“Hot and Dry in the Third degree”. (Avicenna)

Classifications:

2B ATTENUATERS.  2G. CLEANSING.  2H. CARMINATIVES.  2M. DRAWING.  2Q. ANODYNE.  2S. STRENGTHENING
3C. ALEXIPHARMICS3D. CORDIALS & CARDIACS.  3F. LITHONTRIPTIC.  3K. EXPECTORANT.  3L. ANTI-TUSSIVE.  3M. ARTHRITICS
4b. OPTHALMICS4c. CARDIAC.  4d. PECTORAL.  4e. STOMACHIC.  4f. SPLENETIC.  4g. HEPATIC.  4j. NERVINES.  4k. ARTHRITIC

Uses:

1. Benefits the Stomach and Spleen, clears Damp, Tonifies Qi:

-strengthens the stomach and assists digestion “not like a Bitter, but as a warm, invigorating, animating medicine”. (Culpeper)
-strengthens Stomach and increases Spleen Qi deficiency (like Atractylodes Bai Zhu)
-vomiting, diarrhea (Chinese Pharmacopoeia)
-removes ‘Crudities’ (Dampness)
-Hernia, Colic, Wind, Stitches

-“atony of abdominal viscera, with engorgement and relaxation”. (King’s)

2. Move Qi, Eases Pain:

-“useful in all types of Cold pains”. (Avicenna)
-distention in the chest, epigastrium and hypochondria (Chinese Pharmacopoeia)

-bruise or sudden sprain of the Chest with pain during Breathing (Chinese Pharmacopoeia)
-“Enula drives away anger and sadness … According to the testimony of Hippocrates, it is believed to bring cheerfulness, For the sweet cream in it brilliantly disperses the clouds of the mind,”. (Dorsetn, 1540)

3. Clears Cold Phlegm, Stops Cough, Strengthens the Lungs:

-all diseases of the Lungs, Cough, Asthma, shortness of Breath, Whooping Cough
-Lung Ulcers, spitting of Blood

-“The root protects the lungs from bad humors”. (Dorsetn, 1540)
-“it has not its equal in the cure of the Whooping Cough in children when all other medicines fail”. (Culpeper)
-“chronic coughs where the general condition and appetite are reduced”. (Weiss)
-“Cough, of a teasing, persistent character, accompanied with substernal pain, and profuse secretion”. (King’s)

4. Resists Poison, Promotes Sweat:

-biting of Rabid Dogs and other venomous Bites;
-infectious and epidemic diseases, both to prevent and cure

-Herpes, Eczema, putrid Sores and Leprosy
-“great force in the Plague, and Pestilential Fevers”. (Salmon)

-“The root, prepared with honey or sugar, is said to be very effective against pestilential air”. (Dorsetn, 1540)
-“an old German physician claimed to have cured 47 cases of Hydrophobia with Elecampane, without a single failure”. (Ellingwood)

5. Benefits the Kidneys, Clears Damp, Promotes Urine:

-Edema, water retention, stoppage of Urine
-Gravel, Stones
-“The person who is accustomed to take Elecampane regularly will not suffer from frequent urination”. (Avicenna)
-decoction is the best form as a diuretic (Avicenna)

6. Moves the Blood, Promotes Menstruation:

-suppressed, delayed or scanty Menstruation (decocted in wine)
-Pain of the Uterus
-Threatened Abortion (Chinese Pharmacopoeia)
-“strengthening for the Heart”. (Avicenna)

7. Clears Wind, Stops Spasms, Benefits Sinews:

-Cramps, Convulsions, Paralysis
-Gout, Arthritic and Rheumatic pain, Neuralgia
-“looseness of certain joints, by reason of overmuch moisture”; Galen used it for joints prone to dislocation.
-“useful in Sciatica and Arthralgia”. (Avicenna)
-“beneficial for those suffering from sciatica and joint pain … cures pains in the hips”. (Dorsetn, 1540)

8. Benefits Eyesight:

-eye weakness, poor eyesight and to strengthen the sight (Decoction in Wine, Salmon)
-“It nourishes the skin on the face … it adorns the body with perpetual beauty.” (Dorsetn, 1540)

9. Externally:

-externally for Scabs, Itch, Herpes
-old Ulcers and Sores
-fastens the Teeth if the root is chewed.
-wine decoction is gargled for toothache, loose teeth and to prevent putrefaction of the gums
-topically to the joints to tighten loose ligaments, strengthen the joints, and to help remove their pain.
-applied to Sciatica and Hemicrania
-Saline tincture (tincture in salt water) is used as a wash for Dandruff, Spots, Freckles, Herpes, Eczema etc.


CONFECTED ROOT
1. Tonifies Spleen Qi:

-digestive deficiency with weakness, poor appetite, no energy, loose stool
-“Acts directly upon the Nutritive functions of the body. In general debility from protracted disease or from overwork, or from age, its influence is plainly apparent”. (Ellingwood)
-all types of pain in the bowel coming from cold or phlegm (Wirtzung)

2. Nourishes Lungs and Kidneys:

-chronic Cough, Asthma, chronic Lung disease, Consumption from deficiency
-“One of the most beneficial roots nature affords for the help of the Consumptive”.
-pain of the lower back pain or lower body

Dose:

1. Taken with Honey for Cough and Lung complaints. The powder may be mixed with Honey to form a linctus, or a decoction may be made into a syrup with Honey.
2. Taken with Oxymel to clear thick and cold Phlegm.
3. With alcohol to move the Blood and Qi, and ease pain.
Decoction: 3–15 grams
Decoction in Wine (1 in 8): 3–5 oz. twice daily
Powder: 1500mg–5 grams
Tincture (1 in 8 in 40% alcohol): 5–8 mls
Tincture (1 in 5 in 25% alcohol): 2–5 mls, up to 6 or 7 mls.
Fluid Extract (1:1 in 25% alcohol): 1–2 mls, up to 3 mls
Spirit: 1 spoonful (5 mls) or more, diluted in a suitable vehicle
Essential Oil: 6–12 drops, up to 20 drops has been given, mixed with sugar, then dissolved in wine
Juice: 2–3 spoonfuls in Wine
Oily Tincture: 10–30 drops for Convulsions, Cramps, Contraction of the Muscles or Tendons

Comment:

1. I. helenium and I. racemosa are similar in taste, appearance and effect. Inula helenium and I. racemosa are used as the source for a type of Costus (Mu Xiang) in China under the name Tu Mu Xiang, indicating they are used synonymously.
2. Inula and Costus are similar and mutually benefiting, often being used together in the Eastern systems. Inula is a better Qi tonic, Costus is better to regulate Qi. In this way Inula is similar to Atractylodes Bai Zhu, another close relative with similar properties. Together, they mutually enhance. It is also noted that in some parts of China,
3. The preserved Root is a greater tonic, increases Qi and benefits Digestion. It is better for deficiency and chronic diseases of the Lungs and Kidneys; Consumption, lower body weakness, Night Sweats etc.

Preparation:

1. Confected Elecampane:
  It can be preserved to make it more tonifying.
2. Honey and Vinegar Prepared Elecampane:
  Dry Elecampane root, cut small, and steep in vinegar until soft, then take out and dry. The add to a pot with clarified Honey and boil gently into a confection.
  This was specifically used for Pthisick and Shortness of Breath. (Ram’s little Dodeon, 1606)
3. Vinegar Prepared:
  Avicenna
said preserved with Vinegar reduces its heat.

Correctives:

1. Honey
2. Lemon juice (Unani)
3. Coriander seeds. (Tacuinum Sanitatus)

Substitutes:

1. According to Unani sources, Elecampane and Inula racemosa can substitute one another.
2. Atractylodes Bai Zhu can be substituted, especially to strengthen Qi and benefit Digestion.

Main Combinations:

Elecampane & Licorice

Lungs:

1. Cough:
i. acute Cough, Elecampane, Elder berry, Hyssop, Licorice
ii. Cold-Phlegm (‘Wet’) Cough, Elecampane, Rosemary, Sage, Licorice
iii. Cold-Phlegm, Elecampane, Ginger, Licorice
iv. Cold-Phlegm or Wind-Cold, Elecampane, Thyme, Hyssop, Raisins, Licorice
v. Elecampane, Coltsfoot, Licorice, Bitter Almond, Figs
vi. Elececampne, Marshmallow root, Rosemary,
vii. Childhood Cough, Elecampane, Mallow, Plantain and Helichrysum stoechas (this has been studied; see below)
2. Bronchitis:
i. Elecampane with Thyme, Nettle leaf, Lungwort (Fischer)
ii. Elecampane with Myrrh, Mullein, Cinnamon
iii. Elecampane with Elecampane, Coltsfoot
iv. Elecampane with Marshmallow, Hyssop, Thyme
3. Whooping Cough:
i. Elecampane with Thyme
ii. Elecampane, Hyssop, Licorice
iii. Elecmpane, Thyme, Hyssop, Plantain, Raisins
4. Asthma:
i. Elecampane with Coltsfoot, Gentian, Licorice, Hyssop, Sweet Almond, Pine nuts, Dates, Figs (as in Asthmatic Water of Frankfurt)
ii. Tincture Against Asthma, Elecampane with  Orris, Aniseed, Caraway, Licorice, Blessed Thistle, Raisins, Senna.
iii. Elecampane with Angelica, Comfrey, Horehound
iv. Elecampane with Horehound, Coltsfoot, Licorice (as in Decoction of Horehound)
v. Elecampane with Squill, Coltsfoot, Hyssop, Fennel, Marshmallow
vi. Elecampane, Orris, Calamus, Licorice, Aniseed (Anti-Asthmatic Elixir)
5. Shortness of Breath:
i. Elecampane, Hyssop, Coltsfoot
ii. Elecampane, Coltsfoot, Raisins, Licorice
iii. Elecampane, Raisins, Figs, Dates, Bitter Almonds, Pine nuts, Maidenhair, Licorice
iv. Elecampane, Licorice, Saffron
6. Lung deficiency, Cough, Asthma:
i. Elecampane with Licorice, Figs
ii. Elecampane with Fig, Licorice, Comfrey, Coltsfoot (as in Decoction to Strengthen the Lungs)
iii. Elecampane, Raisins, Figs, Dates, Bitter Almonds, Pine nuts, Maidenhair, Licorice
7. Persistent Cough:
i. Elecampane, Raisin, Maidenhair, Licorice
ii. Elecampane with Marshmallow root and Licorice (Ulrich)
8. Chronic catarrh, Asthma, Aneurisms of the Heart, Elecampane with Hyssop and Ground Ivy (Katier)
9. Pectoral Elixir, Elecampane, Orris, Squill (6 each), Benzoin, Myrrh, Gum Ammoniac, Licorice juice (3 parts each), Saffron (2 parts) in alcohol (40%, 65 parts); dose: 60–80 drops. (Hufeland)
10. Pectoral Mixture: Elecampane extract (2 scruples), Gum Arabic (2 drams), Hyssop water (½ oz.), Oxymel of Squill, Syrup of Hyssop (1 ½ oz. each). Mix. Dose:a spoonful. (Formulaire Magistral et Memorial Pharmaceutique, 1823)

Other:

11. Swelling of the Stomach, Lumbar Pain, Gravel & Stone, Phlegm, Colic, Hemorrhoids, to stop excess Menstrual Bleeding, for Cough, Epilepsy and Liver and Spleen disorders, Elecampane 1 oz., Fennel seed 3 oz., Black Pepper 2 oz. Powder and mix with boiled Honey. Give as much as a Hazel nut, either with Oxymel, with Wine, or by itslef. (The Secrets of Alexis, 1615)
12. Pain of the Spleen, take the Powder with Wine. (The Secrets of Alexis, 1615)
13. Hernia:
i. Distill water of Elecampane, 2–3 oz., morning and night. (The Secrets of Alexis, 1615)
ii. Elecampane with Rue (School of Salerno)
iii. Elecampane, Fennel seed, Aniseed
14. Stomach Cold, Elecampane, Cardamon, Galangal (Herbarius latinus, Petri, 1485)
15. Spleen Yang and Qi deficiency, Elecampane with Cinnamon, Galangal, Cumin, Clove, Cardamon, Ginger (as in Powder of Cinnamon Compound of Mesue)
16. Stragnury from Cold, Elecampane, Cinnamon, Galangal, Aniseed, Licorice, Orris, Ginger, Clove, Nutmeg (Herbarius latinus, Petri, 1485)
17. Kidney Yang Deficiency, back pain, impotence, Leukorrhea etc:
i. Elecampane with Nutmeg, Tormentil, Cinnamon, Clove, Mastic (as in Powder of Nutmeg Compound)
ii. Elecampane with Orchis, Black Pepper, Cinnamon, Ginger, Rocket seed (as in Antidote for Cold Kidneys and to Excite Libido of Nicholas)
18. Promote Menstruation:
i. Elecampane with Horehound (Müller)
ii. Elecampane with Mugwort, Betony, Hyssop (as in Decoction to Promote Menstruation)
19. Paralysis:
i. Elecampane with Licorice, Aniseed, Annis, Nutmeg, Peony root (as in Electuary for Paralysis of Wirtzung)
20. Cardiac Edema, combine Elecampane with Foxglove and Compound Celery Syrup.
21. Cachexia, Black Pepper, Elecampane, Fennel root (Pharmacopoeia medici practici universalis, Bruxelles, 1817)
22. Hemorrhoids, Fistulas, Elecampane, Rhubarb, Black Pepper, Licorice, Caraway (equal parts), powder and form a paste with Honey, take a teaspoonful three times daily.
23. Herpes, Elecampane as an ointment with Sulphur
24. To cause suppuration of Abscesses and Tumors, Elecampane powder, White Lily root, applied as a paste with milk or vinegar

INULA RACEMOSA:

1. Cough, Lung disease:
i. Inula racemosa with Adhatoda, Tylophora, Long Pepper
ii. with hard to clear phlegm, Inula racemosa with Basil, Long Pepper, Tylophora
iii. from Wind, Inula racemosa with Adhatoda, Celery seed, Indian Spikenard
iv. from excess Cold Phlegm, Inula racemosa with Mustard seed, Long Pepper, Tylophora
v. Dry Cough, Inula racemosa with Sesame seed, Licorice, Sida
vi. Phlegm Cough, Inula racemosa, Raisins, Triphala (3 Myrobalans), Trikatu (Ginger, Long and Black Pepper), Zedoary, Plumbago, made into a linctus with Honey and Oil. (The Bower Manuscript, Ayurveda)
vii. Cough, Asthma, Inula racemosa with Lesser Cardamon, Sacred Basil, Zedoary, Asafetida
2. Allergic Rhinitis, Atopic Asthma, Inula racemosa with Chebulic Myrobalan, Long Pepper, Licorice
3. Cold and Weak digestion:
i. Inula racemosa with Ginger, Cardamon
ii. Inula racemosa with Ginger, Plumbago, Cumin
4. Dysmenorrhea, Inula racemosa with Turmeric, Rose, Asparagus root
5. Angina pectoris, Hypertension, Inula racemosa with Arjuna, Bdellium

Major Formulas

Decoction of Elecampane and Rue
Decoction of Horehound
Decoction to Strengthen the Lungs
Syrup for Asthma (Wirtzung)
Powder of Cinnamon Compound (Mesue)
Electuary of Clove and Costus (Caryocostinum)
Electuary of Elecampane (Unani)
Electuary for Paralysis (Wirtzung)
Electuary which is Remarkably Effective
Antidote for Cold Kidneys and to Excite Libido (Nicholas)
Tincture Against Asthma
Elixir Salutis, Elixir of Health
Eight-Limbed Electuary (Ayurveda)
Auscpicious Conqueror (Bkra shis rnam rgyal) (Tibetan)
Blood Medicine 7 (Khrag sman bdun pa) (Tibetan)
Cloudless Moonbeam (Sprin bral zla ‘od) (Tibetan)
Cowrie Ash 6 (Mgron thal drug pa) (Tibetan)
Eliminator of All Lung Imbalances (Khrugs glo bcu gsum) (Tibetan)
Increase Awareness Pills (Tibetan)
Inula 4 Decoction (Ma nu bzhi thang) (Tibetan) 
Podophyllum 25 (‘Ol se nyer lnga) (Tibetan)
Six White Formula (Dkar po drug sbyor) (Tibetan)

1. Compound Syrup of Elecampane:.
Roots of Elecampane; Polypody, Currants 2 oz. ea., Sebestens 15 (in number), Coltsfoot, Lungwort, Calamint, Savory 1 handful ea., Licorice 2 drams, Seeds of Nettles and the Cotton plant 1 ½ drams ea., 1 large Tobacco leaf
Boil in Honey and Wine down to 1 ½ lbs, then with a sufficient amount of Sugar, make a syrup from the strained decoction.
Used for diseases of the Lungs coming from phlegm
“Invented by Horatius Augenius, and afterwards recommended by Platerus, Sennertus, Riverius, and other famous practitioners … and ought to be frequently made use of”. (The London Practice of Physic; Willis, 1689)
2. Anti-Asthmatic Water:
i. Elecampane, Licorice, Florentine Orris (2 oz. each), Ground Ivy, Coltsfoot, Jerusalem Oak (
½pound), Hyssop, Horehound, Pennyroyal, Sage (3 oz. each). Annis, Fennel seed (1 oz). Digest 3 days, then distil 6 or 7 pounds. (Pharmacopoeia Wirtembergica, 1798)
ii. Elecampane (2 oz.), Burnet Saxifrage root, Florentine Orris (1 ½ oz. ea.), Hyssop, Horehound, Sage (2 oz. each), Annis, Fennel seed, Juniper berry, Bay berry (1 oz.), Lesser Cardamon, Cinnamon, Ginger (½oz. each), Storax (6 drams), Alcohol (12 pounds), Water of Acacia (8 lbs.). Digest 3 days, distil off 12 pounds, then add: Rose Julep (2 pounds), Fennel water (8 pounds). Mix. (Dispensatorium Pharmaceuticum, 1777)
3. Anti-Asthmatic Elixir:
Stimulant, principally for humid Asthma. Dose: 10–30 dops.
i. Asarum root (3 parts), Florentine Orris (5 parts), Elecampane, Calamus (10 parts each), Licorice (15 parts), Aniseed (5 parts), Proof Spirit (80 parts). Infuse cold for several days, strain, and add Camphor (1 part). Dissolve. (Pharmacopee Usuelle, Louvain, 1821)
4. Theriacal Vinegar:
Used to preserve against Contagion.
i. Roots of Elecampane, Angelica, Cyperus, Zedoary, Avens, Contrayerva, Materwort, Valerian, Vipers Bugloss (½ oz. each), fresh Orange and Lemon peel, Clove, Cinnamon, Galangal, Juniper, Bay berry, Sage, Rosemary, Rue (2 drams each), Vinegar (7 lbs.). Macerate for a month in a warm place, express strongly, then add Theriac (7 oz.), Macerate for a month, and filter. Dose: a spoonful every morning. (Dispensatorium medico pharmaceuticum Palatinatus, 1764)
5. Courcelle’s American Elixir:
i. Elecampane (16 lbs.), St. Johns wort (8 lbs.), Orange leaf (6 lbs.), Elder flower (5 lbs.), Balm (4 lbs.), Lime flower (2 ½ lbs.), Root of Provence Cane, Juniper, Rosemary flowers, Opium (2 lbs.), Asarum root (1 lb.), Alcohol (120 lbs.), Water, sufficient to make 24% alcohol. Digest, strain and color with Red Poppy flowers.
  This was highly regarded as a Panacea in American for a time. Specifically used for nervous spasms and for general debility.
Dose: a large spoonful, 2–3 times daily. (This version is reformed from Formulaire Magistral et Memorial Pharmaceutique, 1823)
6. Compound Oil of Elecampane:
i. Elecampane, Valerian, Burdock, St. Johns wort, Sothernwood, Wormwood, Sweet Basil, Balm, Balsamita odorata, Marjoram, Mint, savin, Sage, Elder flower (3 oz. each), Camomile, Meliot, Stoechas (2 oz. each), fresh Bay leaf, Dwarf Elder leaf, Rosemary, Rue (6 oz. each), Cumin, Fenugreek, Nettle (1 oz. each), Olive oil (12 lbs.). Macerate 4 days, then boil to the consumption of the humidity, and set aside to clarify (settle). (Pharmacopoeia Hispana, 1798)

Cautions:

1. Used cautiously during Pregnancy.

Main Preparations used:

Candied and Conserved root, Distilled Water, Extract of the Root and a Wine

1. Pastilles of Elecampane:
i. Powdered Elecampane (
½oz.), Florentine Orris (1 dram), mucilage of Tragacanth (sufficient). Form Pastilles. Used for scurvy, Edema, Chlorosis. Dose: ½oz. (Formulaire Magistral et Memorial Pharmaceutique, 1823)
2. Water Extract of Elecampane:
i. Fresh Elecampane root and quantity. Wash well, rasp it and express the juice. Bruise the residue with a little water and express. Strain the liquor through flannel, and evaporate with gentle heat to an extract.
(Pharmacopee Usuelle, Louvain, 1821)
ii. Elecampane root (1 pound), Water (6 lbs.). Macerate for 4 days warm, then boil a little; express and evaporate. (Dispensatorium Pharmaceuticum, 1777)
3. Alcohol Extract of Elecampane:
i. Elecampane (1 pound), Alcohol (5 pounds); digest, extract, strain with strong expression; digest, then boil the residue in Water (3 lbs.). Clarify the decoction with a egg white, then mix the two liquors together, distil off the alcohol, and evaporate to a proper consistency.
(Pharmacopoeia Wirtembergica, 1798)
ii. Elecampane, Alcohol, Water (equal parts). Digest 12 hours, express, distil off the alcohol, then evaporate to a proper consistency. (Pharmacopoeia regni Poloniae, 1817)
4. Distilled Water of Elecampane:
i. Fresh Elecampane root (1 part), water (5 parts). Distil 2 parts.
(Pharmacopoeia Gallica, 1818)
Strengthens the Stomach and Lungs, promotes Urine and cleanses Gravel.
5. Wine of Elecampane:
i. Fresh Elecampane root (1 part), White Wine (16 parts). Digest without heat for several days, express and filter.
(Pharmacopee Usuelle, Louvain, 1821)
ii. “Take Must (New Wine) trodden out of the Grapes, and let it seethe without any smoke about it even to the half if that you desire to have it sweet. In this are you to seethe Elecampane roots, which be digged up in the Spring time, and cut into slices and dried on a thread. Seethe them so long in it until they have lost all their bitter taste: and if one will often use this wine, then are the roots so much the oftener to be sod with new wine, that the wine may abide by his power, and the vessel is always to be filled up again with wine”.
“This is a very profitable potion for the head and brains, in like manner also for to warm and strengthen the sinews if the same be vexed with Rheums. This wine is also good against all cold diseases of the lights, and of the breast; it cleanses the same, it strengthens all bad digestive stomachs, it refreshes natural warmth, it warms the sinews, it opens the passages of urine, it is good against all winds, it strengthens the Matrix, and it cleanses the same of all cold phlegmatic moisture, and it provokes the Terms”. (Wirtzung)
6. Tincture of Elecampane:
Stimulant, carminative, principally for Lung diseases. Dose: 6 drops–1 dram
i. Elecamapane (1 part), Alcohol (6 parts). Digest, strain, filter.
ii. Elecampane root (1 oz.), Alcohol 20% (4 oz.). Infuse in a water-bath for 4 days, strain, and pour upon the residue Alcohol (2 oz.); macerate again for 2 days, strain, mix, filter.
7. Ointment of Elecampane:
i. Elecampane root (
½pound), Spring water (128 oz.). Boil, reduce to a pulp, and add Fresh Butter (4 oz.). Mix. (Niemann)
ii. Elecampane root (1 pound), Lard (
½pound), Olive oil (4 oz.). Beat in a stone mortar then boil over a slow fire until the consumption of the humidity, express, strain and add: Yellow Wax, Turpentine (1 oz. each). Mix. (Dispensatorium Pharmaceuticum, 1777)


Click the above Tabs for more information on this medicine

-From the School of Salerno (taken from the English version by Sir John Harington):

Elecampane strengthens each inward part,
A little looseness is thereby provoken,
It swages grief of mind, it cheers the Heart,
Allaieth wrath, and makes a man fair spoken:

-From an old Latin herbal: “Elecampane will the Spirits sustain”.
Pliny said: “Julia Augusta, let no day pass without eating some of the roots of Enula condired, to help digestion, and cause mirth”.
-In older times, it was commonly used to treat cutaneous diseases of Sheep, Cattle and Horses, being used as a wash.
-The Spanish hang fresh bunches of the herb in their houses which attracts flies to it, and at night time when all the flies have been caught in the sticky leaves, the whole is put into a bag and plunged into water to drown the flies.


Pharmacographia, Fluckiger & Hanbury, 1879
The plant was known to the ancient writers on agriculture and natural history, and even the Roman poets were acquainted with it, and mention Inula as affording a root used both as a medicine and  a condiment. Vegetius Renatus, about the beginning of the 5th century, calls it Inula Campana, and St. Isidore in the beginning of the 7th names it as Inula, adding—”quam Alum rustici vocant.” It is frequently mentioned in the Anglo-Saxon writings on medicine current in England prior to the Norman Conquest; it is also the “marchalan” of the Welsh Physicians of the 13th century and was generally well known during the middle ages. Not only was its root much employed as a medicine, but it was also candied and eaten as a sweetmeat“.

GENERAL / REVIEW:
Synthetic and Pharmacological Activities of Alantolactone and Its Derivatives.
Isoalantolactone: a review on its pharmacological effects.
Biological Activities and Chemical Profile of Gentiana asclepiadea and Inula helenium Ethanolic Extracts.
Bioactive sesquiterpenes from Inula helenium.
ANTIBACTERIAL:
From Monographs to Chromatograms: The Antimicrobial Potential of Inula helenium L. (Elecampane) Naturalised in Ireland.
Antimicrobial activity of Inula helenium L. essential oil against Gram-positive and Gram-negative bacteria and Candida spp.
In vitro activity of Inula helenium against clinical Staphylococcus aureus strains including MRSA.
ANTI-INFLAMMATORY:
Inula helenium and Grindelia squarrosa as a source of compounds with anti-inflammatory activity in human neutrophils and cultured human respiratory epithelium.
Anti-inflammatory effects of isoalantolactone on LPS-stimulated BV2 microglia cells through activating GSK-3β-Nrf2 signaling pathway.
CONTAINS B12:
Isolation and analysis of vitamin B12 from plant samples.
LUNG INJURY:
Isoalantolactone suppresses LPS-induced inflammation by inhibiting TRAF6 ubiquitination and alleviates acute lung injury.
Isoalantolactone protects LPS-induced acute lung injury through Nrf2 activation.
COUGH:
Efficacy and safety of the syrup “KalobaTUSS®” as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial.
PNEUMONIA:
Isoalantolactone protects against Staphylococcus aureus pneumonia.
TUBERCULOSIS:
A review of medicinal plant of Middle East and North Africa (MENA) region as source in tuberculosis drug discovery.
NEUROPROTECTIVE:
Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells.
DEPRESSION:
Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.
ANTI-HYPERTENSIVE:
Alantolactone mitigates the elevation of blood pressure in mice induced by angiotensin II by inhibiting calcium channel activation.
DERMATITIS:
Igalan from Inula helenium (L.) suppresses the atopic dermatitis-like response in stimulated HaCaT keratinocytes via JAK/STAT3 signaling.
Total sesquiterpene lactones isolated from Inula helenium L. attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice.
PSORIASIS
Alantolactone Suppresses Proliferation and the Inflammatory Response in Human HaCaT Keratinocytes and Ameliorates Imiquimod-Induced Skin Lesions in a Psoriasis-Like Mouse Model.
RHEUMATOID ARTHRITIS:
Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis.
PREBIOTIC:
Determination of prebiotic activity and probiotic encapsulation ability of inulin type fructans obtained from Inula helenium roots.
PROTECTS FROM SMOKING DAMAGE:
Alantolactone suppresses inflammation, apoptosis and oxidative stress in cigarette smoke-induced human bronchial epithelial cells through activation of Nrf2/HO-1 and inhibition of the NF-κB pathways.
ANTI-ANGIOGENIC:
Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling.
CYTOTOXIC:
Cytotoxicity of some Russian ethnomedicinal plants and plant compounds.
ANTIPROLIFERATIVE:
Antiproliferative sesquiterpene lactones from the roots of Inula helenium
ANTI-TUMOR:
Antitumour activities of sesquiterpene lactones from Inula helenium and Inula japonica.
[Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].
Tumor cell specific toxicity of Inula helenium extracts.
CANCER
Investigation of the sensitivity of human A549 cells to paclitaxel and sesquiterpene lactone alantolactone via apoptosis induction.
Alantolactone: A Natural Plant Extract as a Potential Therapeutic Agent for Cancer.
Targeting apoptosis pathways in cancer with alantolactone and isoalantolactone.
Tumor cell specific toxicity of Inula helenium extracts.
BREAST:
Sesquiterpene lactones-enriched fraction of Inula helenium L. induces apoptosis through inhibition of signal transducers and activators of transcription 3 signaling pathway in MDA-MB-231 breast cancer cells.
Apoptosis induction by alantolactone in breast cancer MDA-MB-231 cells through reactive oxygen species-mediated mitochondrion-dependent pathway.
Alantolactone, a sesquiterpene lactone, inhibits breast cancer growth by antiangiogenic activity via blocking VEGFR2 signaling.
Isoalantolactone inhibits the migration and invasion of human breast cancer MDA-MB-231 cells via suppression of the p38 MAPK/NF-κB signaling pathway.
High throughput screening of natural products for anti-mitotic effects in MDA-MB-231 human breast carcinoma cells.
Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice.
CERVICAL:
Alantolactone Induced Apoptosis and DNA Damage of Cervical Cancer through ATM/CHK2 Signaling Pathway.
COLORECTAL:
The Sesquiterpene Lactone-Rich Fraction of Inula helenium L. Enhances the Antitumor Effect of Anti-PD-1 Antibody in Colorectal Cancer: Integrative Phytochemical, Transcriptomic, and Experimental Analyses.
Isoalantolactone induces apoptosis through reactive oxygen species-dependent upregulation of death receptor 5 in human esophageal cancer cells.
ESOPHAGEAL:
Alantolactone inhibits oesophageal adenocarcinoma cells through nuclear factor erythroid 2-related factor 2-mediated reactive oxygen species increment.
Inhibition of Growth of Esophageal Cancer by Alantolactone via Wnt/β- Catenin Signaling.
GALL BLADDER:
Isoalantolactone suppresses gallbladder cancer progression via inhibiting the ERK signalling pathway.
GASTRIC:
Potent inhibition of gastric cancer cells by a natural compound via inhibiting TrxR1 activity and activating ROS-mediated p38 MAPK pathway.
GLIOBLASTOMA:
Antioxidant and anticancer activities of extract of Inula helenium (L.) in human U-87 MG glioblastoma cell line.
LEUKEMIA:
Targeting non-oncogene ROS pathway by alantolactone in B cell acute lymphoblastic leukemia cells.
Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway.
Sesquiterpenoids from the roots of Inula helenium inhibit acute myelogenous leukemia progenitor cells.
Costunolide promotes imatinib-induced apoptosis in chronic myeloid leukemia cells via the Bcr/Abl-Stat5 pathway.
[Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].
LYMPHOMA:
[Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].
LIVER:
Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway
LUNG:
Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation.
Antitumor activity of alantolactone in lung cancer cell lines NCI-H1299 and Anip973.
Alantolactone induces apoptosis, promotes STAT3 glutathionylation and enhances chemosensitivity of A549 lung adenocarcinoma cells to doxorubicin via oxidative stress.
MELANOMA:
Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells.
OSTEOSARCOMA:
Alantolactone inhibits proliferation, metastasis and promotes apoptosis of human osteosarcoma cells by suppressing Wnt/β-catenin and MAPKs signaling pathways.
OVARIAN:
Isoalantolactone Suppresses Glycolysis and Resensitizes Cisplatin-Based Chemotherapy in Cisplatin-Resistant Ovarian Cancer Cells.
PANCREATIC:
Isoalantolactone inhibits pancreatic cancer proliferation by regulation of PI3K and Wnt signal pathway.
Active ingredients of Inula helenium L. exhibits similar anti-cancer effects as isoalantolactone in pancreatic cancer cells.
Alantolactone induces apoptosis and improves chemosensitivity of pancreatic cancer cells by impairment of autophagy-lysosome pathway via targeting TFEB.
Ethyl acetate extract from Inula helenium L. inhibits the proliferation of pancreatic cancer cells by regulating the STAT3/AKT pathway.
PROSTATE:
Isoalantolactone Increases the Sensitivity of Prostate Cancer Cells to Cisplatin Treatment by Inducing Oxidative Stress.
TESTICULAR:
Anticancer potential of isoalantolactone in testicular cancer: an analysis of cytotoxicity, apoptosis, and signaling pathways.
THYROID:
Alantolactone induces concurrent apoptosis and GSDME-dependent pyroptosis of anaplastic thyroid cancer through ROS mitochondria-dependent caspase pathway.
SYNERGISTIC WITH CHEMOTHERAPY:
Isoalantolactone Enhances the Antitumor Activity of Doxorubicin by Inducing Reactive Oxygen Species and DNA Damage.
Alantolactone enhances gemcitabine sensitivity of lung cancer cells through the reactive oxygen species-mediated endoplasmic reticulum stress and Akt/GSK3β pathway.
Costunolide enhances sensitivity of K562/ADR chronic myeloid leukemia cells to doxorubicin through PI3K/Akt pathway

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