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Viola, Violet

Banafsha (Unani)
Zi Hua Di Ding  紫花地丁 (TCM)
Sngo Rta Rmig
  སྔོ་ རྟ་རྨིག་ (Tibet)
Picture
Ortus Sanitatis, Meydenbach, 1491

Picture
Picture
V. odorata
New Kreuterbuch
, Matthiolus, 1563

V. odorata
Kurtzes Handtbuchlein
, Ryff, 1599
Picture
V. odorata
Plantæ Utiliores
, Burnett & Burnett, 1842

Picture
V. biflora (used in Tibetan Medicine)
Lindman, C.A.M., Bilder ur Nordens Flora (1922)

Botanical name:
Viola spp.:
  1. Western: V. odorata
  2. TCM: V. philippica (syn. V. yedoensis, V. alisoviana), V. betonicifolia, V. patrini
  3. Tibet: V. biflora
The basic effects of the the Violet species can be considered close enough to be synonymous. The Western V. odorata is perhaps stronger in effect and has the advantage of calming the mind for which the flowers are regarded as strongest.

Parts used:
Leaf, Flower; rarely the Seed or Root

Temperature & Taste:
Cool, moist. Sweet, Bitter

Classifications:
2E LENITIVE.    2F. PURIFYING.    2J. RAREFYING.    2L. EMOLLIENT.    2U. SUPPURATIVE.   
3B. FEBRIFUGE & ANTIPYRETIC.     3C. ALEXIPHARMIC.    3D. CORDIALS & CARDIACS.    3L. ANTI-TUSSIVE.    3M. ARTHRITIC
4a. CEPHALIC.   4c. CARDIAC.   4d. PECTORAL.   4e. STOMACHIC.   4f. SPLENETIC.   4g. HEPATIC.   4h. NEPHRITIC.   4i. UTERINE.   4j. NERVINE
Preparers and Purgers of Bile
TCM:
B. Clears Heat and Toxin      B. Clears Deficient Heat

Uses:
1. Clears Heat, Resists Poison:
-skin diseases with Heat and Poison such as Boils, Sores, Eczema
-acute sore or swollen Throat for which it may be used as a gargle.
-Scrofula, Syphilis and Rheumatism, and traditionally for venomous Bites
-seed has also been used for the stinging of Scorpions.


2. Clears Heat, Nourishes Yin, Resolves Swellings:
-conditions where the
Yin has been damaged by Heat: Thirst of Fevers, Night Sweats, Consumption, Cachexia, wasting disorders.
-
‘Ripen and dissolve Swellings’ including Scrofula, swollen nodes
-Tumors and Cancer including that of the Breast, Throat, Tongue, Lungs, Liver, Intestine, Lymph nodes, Soft Tissue etc.
-prevents metastases following surgical removal. (BHP specific)


3. Clears Heat, Calms the Mind, Stops Spasms, Eases Pain:
-irritability, restlessness and insomnia from heat as seen in Fevers, especially in Children
-over-excited children, or those with poor concentration.
-strong pain from Wind and Heat including severe Headaches
-early stages of Epilepsy and other nervous disorders
-'Powerful relaxant' (Galen)


4. Clears Heat and Phlegm, Stops Cough:
-severe coughs such as Whooping Cough, relieves pleurisy, hoarse throats, bronchitis and various Coughs.
-Shortness of breath associated with Heat or dryness.


5. Clears Heat and Damp:
-Jaundice, Cholecystitis, Gall Stones;
-hot urinary conditions such as scanty or painful urine; it has been used for Nephritis.
-accessory herb for Rheumatism and Gout.


6. Gentle Purgative and Emetic:
-Roots are emetic and purgative
-The roots were said to be superior to all
other emetics; ‘a valuable substitute for Ipecacuanha’.
-The herb is used as
a mild purgative, especially in heat diseases of children.
-Seed promotes Labor and kills Worms (Galen)


7. Externally:
-Poultices, Plasters and Ointments to all Swellings, Tumors and Cancers of the flesh and Breast.
-applied to Lymphatic Swellings.

-Infused Oil, Ointment or Poultice is good for all Heat and Inflammations, Burning and Hectic Fevers (applied to the Heart and Pulses)
-heat-type Pain in the Breast and Lungs.

-applied to the Head to abate the pain of Headaches
-decoction is used for Prolapses of the Uterus and Rectum



NOTE:
1. Violet leaf is one of the Five Emollient Herbs, along with Marshmallow, Beet, Mercury, Pellitory of the Wall, and Mallow
2. Violet flower is one of the
Four Cordial Flowers, along with Rose, Bugloss and Borage.
3. The fresh plant is always preferred, and of that, the Flower is best.
4. The Flowers were most kept in the form of the Conserve; the Juice of the Whole Plant may be made into a Syrup to keep.

DOSE:
In INFUSION or BRIEF DECOCTION of the Whole Herb: 3–9 grams, up to 30 grams daily (dried), or 10–30 grams, up to 2 oz. fresh. In the Treatment of Cancer and other serious or chronic disease, or when used as a single herb, 1 oz. of the dried or 2 ½ oz. of the fresh leaves are steeped overnight in 1 pint of boiling water, and this is taken over the course of the following day;
Of the TINCTURE (1:5 in 25% alcohol, the fresh plant tincture being best): 2–4, or 6 mls, up to 10, 15, or 20 mls for tumors and swellings, 2–3 times daily;
Of the FLUID EXTRACT (1:1: in 25% alcohol): 2–4 mls, up to 6 mls, 2–3 times daily;
Of the ROOT in POWDER: 1 ½–4 grams (normally 2 ½–3 grams is an Emetic for an adult);
Of the STEMS in INFUSION: 1–2 oz. (as an emetic and purgative);
Of the FLOWERS in POWDER: 250mg–1 gram (conserve of the flowers is best; see below).

CORRECTIVES:
1. Water Lily (Unani)
2. Marjoram (Unani)

SUBSTITUTES:
1. Mallow (Unani)
2. Borage (Unani)

Main Combinations:
Dandelion & Violet

1. Cough:
i. Violet with Marshmallow
ii. Violet with Plantain leaf and Licorice
2. Whooping Cough, Violet with Sundew and Peony root (Kroeber)
3. Asthma:
i. Violet with Bitter Almond, Marshmallow, Licorice, Tragacanth, Fennel seed (as in Electuary for Asthma)
ii. Violet with Elecampane, Licorice, Sage, Maidenhair, Coltsfoot, Hyssop, Thyme, Aniseed (as in Syrup for Asthma)
4. Pleurisy, Violet with Melon seed, Mallow seed, Gum Arabic, Tragacanth (as in Syrup of Violet)
5. Allergic Rhinitis, Violet with Eyebright, Calendula, Wormwood
6. Heat of the Blood:
i. Violet with Meliot, White Dead Nettle, St. Johns wort (Zimmermann)
ii. Violet with Sorrel, Mallow, Plantain, Purslane, Endive (as in Decoction to Cool the Blood)
7. To purge Melancholy:
i. Violet with Polypody and Senna
ii. Violet with Senna, Polypody, Ginger, Raisin, Prune, Borage (as in Decoction of Senna)
iii. Violet with Dill seed, Aniseed, Licorice, Sorrel, Endive, Polypody, Mastic, Cinnamon (as in Powder of Polypody of Montagnana)
8. To clear Heat and Bile:
i. Violet with Borage, Chicory, Agrimony
ii. Violet with Prune, Tamarind, Barley, 4 Cold seeds (as in Decoction to Cool)
iii. Violet with Endive, Chicory, Agrimony, Borage, Tamarind, Licorice (as in Decoction to Expel Bile of Andernacus)
9. Skin diseases from Bile or Melancholy, Violet with Yellow Myrobalan, Dodder, Wormwood, Fumitory (as in Syrup of Fumitory Lesser of Mesue)
10. Nervous over-stimulation, insomnia and hysteria, Violet with Balm, Valerian, Yarrow (Schmidt)
11. Insomnia, Violet, Lettuce seed, Saffron
12 Migraine, Violet, Damask Rose, Coriander seed (this has been studied; see below).
13. Madness and Mental illness, Water Lily flower, Violet flower, Rose, Lettuce seed, Poppy seed, Red Coral, Red Sandalwood (as in Powder for Madness)
14. Palpitation, Arrhythmia, Fainting, Vertigo, Migraine, Violet with Rosemary, Rose, Licorice, Clove, Indian Spikenard, Nutmeg, Cinnamon, Ginger, Zedoary, Aloeswood, Cardamon (as in Powder of Rosemary)

Major Formulas:
Decoction of Fruit
Syrup of Fumitory Lesser (Mesue)
Syrup of Violet Compound
Syrup of Violet (De morbus internis curandis)
Syrup of Jujube Compound (Mesue)
Syrup of Water Lily Flowers
Powder of Rosemary Compound (Dianthos) (Nicholas)
Electuary for Asthma (1) (De Morbis internis curandis, 1551)
Electuary to Restore Humidity (Arnold de Villa Nova)
Electuary of Prunes (Diaprunis lenitiva) (Nicholas)

Cautions:
Generally Safe. ‘Mild Nature, in no way harmful’ (Culpeper)
1. Use cautiously in cold and weak digestive systems.
2. Large doses should be avoided in children.

TOXICITY:
No obvious toxic effects were noted in animals receiving water extracts of up to doses of 1.6g/kg.

Main Preparations used:
Solutive Syrup of Violets, Syrup of the Juice, Compound Syrup, Julep of Violets, Conserve of the Flowers, Infused Vinegar of the Flowers, Infused Oil, Distilled Water of the herb and of the flower, Tincture, Extract of the Juice Dehydrated, Troches

1. Conserve of Violet flower:
i. Fresh Violet flowers (1 part), White Sugar (2 parts). Beat.

2. Violet Water:
i. Violet flowers (1 part), Water (4 parts). Infuse 6 hours, distil 2 parts. (
Pharmacopoeia Sardoa, 1773)

3. Syrup of Violet:
i. Violet flowers (2 parts), Boiling Water (8 parts), White Sugar (15 parts). Macerate flowers for 24 hours, strain and add the Sugar.

4. Oil of Violets:
i. Violet petals (1 ½ parts), Olive oil (3 parts). Digest in a gentle heat for 2 days; express, and repeat with fresh flowers. (Pharmacopoeia Sardoa, 1773)

Research
GENERAL / REVIEW
–A Critical Review on Phytochemistry, Pharmacology of Viola odorata L. and Related Multipotential Products in Traditional Persian Medicine.

ANTIBACTERIAL
–Natural bioactive compounds from medicinal plants as antibacterial drugs: mechanism insights and clinical perspectives.
–In vitro and in vivo anti-Helicobacter pylori activity of selected medicinal plants employed for the management of gastrointestinal disorders.
–Comparison of the antimicrobial effects of semipurified cyclotides from Iranian Viola odorata against some of plant and human pathogenic bacteria.
–Composition of essential oil and biological activity of extracts of Viola odorata L. from central Iran.
–The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria.

ANTIFUNGAL
–PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata.

ANTIOXIDANT
–Studies on antioxidant, hepatoprotective, and vasculoprotective potential of Viola odorata and Wrightia tinctoria.
–Composition of essential oil and biological activity of extracts of Viola odorata L. from central Iran.
–Antioxidant and free radical scavenging activity of H. officinalis L. var. angustifolius, V. odorata, B. hyrcana and C. speciosum.

ANTIPYRETIC
–The Effect of Viola Odorata L. Oil for Fever in Children: A Randomized Triple-blinded Placebo-controlled Clinical Trial.
–Antipyretic studies on some indigenous Pakistani medicinal plants.

COUGH & ASTHMA
–The Effect of Viola odorata Flower Syrup on the Cough of Children With Asthma: A Double-Blind, Randomized Controlled Trial.

ALLERGIC RHINITIS
–Efficacy of Sweet Violet (Viola odorata) flower oil on the symptoms of adults with allergic rhinitis: A double-blind randomized placebo-controlled clinical trial.

SEDATIVE / INSOMNIA
–Evaluation of sedative effects of an intranasal dosage form containing saffron, lettuce seeds and sweet violet in primary chronic insomnia: A randomized, double-dummy, double-blind placebo controlled clinical trial.
–Effects of Viola odorata as an Add-On Therapy on Insomnia in Patients with Obsession or Depression: A Pilot Randomized Double-Blind Placebo-Controlled Trial.
–Efficacy of Violet oil, a traditional Iranian formula, in patients with chronic insomnia: A randomized, double-blind, placebo-controlled study.
–Efficacy of Viola odorata in Treatment of Chronic Insomnia.

HEPATOPROTECTIVE
–Studies on antioxidant, hepatoprotective, and vasculoprotective potential of Viola odorata and Wrightia tinctoria.
–Modulatory effects of Viola odorata flower and leaf extracts upon oxidative stress-related damage in an experimental model of ethanol-induced hepatotoxicity.
DIABETES
–In Silico Prediction of the Mode of Action of Viola odorata in Diabetes.

VASCULOPROTECTIVE
–Studies on antioxidant, hepatoprotective, and vasculoprotective potential of Viola odorata and Wrightia tinctoria.

ANTI-HYPERTENSIVE
–Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial.
–Studies on the antihypertensive and antidyslipidemic activities of Viola odorata leaves extract.

NEUROPROTECTIVE
–The mechanism of neuroprotective effect of Viola odorata against serum/glucose deprivation-induced PC12 cell death.
–Protective effect of Viola tricolor and Viola odorata extracts on serum/glucose deprivation-induced neurotoxicity: role of reactive oxygen species.

ANTIDEPRESSANT
–Antidepressant potential of novel flavonoids derivatives from sweet violet (Viola odorata L): Pharmacological, biochemical and computational evidences for possible involvement of serotonergic mechanism.

MEMORY ENHANCEMENT
–Pharmacological Screening of Viola odorata L. for Memory-Enhancing Effect via Modulation of Oxidative Stress and Inflammatory Biomarkers.

MIGRAINE
–Efficacy of combination of Viola odorata, Rosa damascena and Coriandrum sativum in prevention of migraine attacks: a randomized, double blind, placebo-controlled clinical trial.

BRAIN INJURY
–Role of Herbal Medicines in the Management of Brain Injury.

BENIGN PROSTATIC HYPERPLASIA
–A two-week, double-blind, placebo-controlled trial of Viola odorata, Echium amoenum and Physalis alkekengi mixture in symptomatic benign prostate hyperplasia (BPH) men.

CANCER
–PepSAVI-MS reveals anticancer and antifungal cycloviolacins in Viola odorata.
–Anticancer and chemosensitizing abilities of cycloviolacin 02 from Viola odorata and psyle cyclotides from Psychotria leptothyrsa.
BREAST
–Suppressive role of Viola odorata extract on malignant characters of mammosphere-derived breast cancer stem cells.
–The synergistic cytotoxic effects of doxorubicin and Viola odorata extract on human breast cancer cell line T47-D.
–Inhibitory Effect of Viola odorata Extract on Tumor Growth and Metastasis in 4T1 Breast Cancer Model.

ANTHELMINTIC
–The anthelmintic activity of the cyclotides: natural variants with enhanced activity.

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