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Morinda, Ba Ji Tian 巴戟天
Indian Mulberry
Ba Ji Tian (TCM)
Ba Ji Tian (TCM)
Morinda in Gujin Tushu Jicheng (Imperial Encyclopedia, early 18th century)
Botanical name:
Morinda officinalis
Parts used:
Root
Temperature & Taste:
Warm, dry. Sweet, Pungent
Classifications:
N. Yang Tonics
Morinda officinalis
Parts used:
Root
Temperature & Taste:
Warm, dry. Sweet, Pungent
Classifications:
N. Yang Tonics
Uses:
1. Strengthens Kidneys, Tonifies Yang:
-Impotence, Premature Ejaculation, Spermatorrhea
-Urinary frequency, Incontinence
-Infertility in male or female, irregular Menstruation
-Menopausal Syndrome
-Cold pain in the lower abdomen, Back pain and weakness
-'reinforces Essence' (Ming Yi Bie Lu); increases Qi (Shen Nong Ben Cao)
-recently used for Depression and Alzheimer's Disease
2. Clears Wind-Damp, Benefits the Sinews and Bones:
-wind-cold painful obstruction of the bones and joints (especially with Kidney deficiency)
-lower back pain, weakness and tension
-stiffness, difficulty moving; weakness of the legs
-Osteoporosis (proven effect)
Dose:
Decoction: 6–15 grams
Powder: 2–5 grams
Preparation:
1. Stir-fried Morinda Ba Ji Tian:
Stir-fry Morinda root with glutinous rice in a dry wok until the rice tuirns yellow.
2. Wine-prepared Morinda Ba Ji Tian:
Soak the root in wine overnight, then dry.
Decoction: 6–15 grams
Powder: 2–5 grams
Preparation:
1. Stir-fried Morinda Ba Ji Tian:
Stir-fry Morinda root with glutinous rice in a dry wok until the rice tuirns yellow.
2. Wine-prepared Morinda Ba Ji Tian:
Soak the root in wine overnight, then dry.
Main Combinations:
1. Impotence, Spermatorrhea, and Premature Ejaculation from Kidney Yang deficiency:
i. Morinda Ba Ji Tian with Cistanche Rou Cong Rong and Cuscuta Tu Si Zi.
ii. Morinda Ba Ji Tian with Cistanche Rou Cong Rong, Eucommia Du Zhong, Placenta
iii. or Male Infertility, Morinda Ba Ji Tian with Raspberry fruit (Fu Pen Zi), Cistanche Rou Cong Rong, Velvet Deer Horn (Lu Rong)
2. Impotence, Infertility:
i. Morinda Ba Ji Tian with Ginseng and Dioscorea Shan Yao.
ii. Morinda Ba Ji Tian with Cinnamon, Cnidium She Chuang Zi, Cistanche Rou Cong Rong
3. Increase Sperm Quality and Quantity, Morinda Ba Ji Tian with Dodder seed (Tu Si Zi),
4. Coldness of the Womb, irregular Menses, and leukorrhea Morinda Ba Ji Tian with Galangal (Gao Liang Jiang), Wisteria (Zi Teng), Cinnamon Bark, and Evodia Wu Zhu Yu (as in Ba Ji Wan, from Imperial Grace Formulary of the Tai Ping Era),
5. Lower Back pain, Joint pain:
i. Morinda Ba Ji Tian with Eucommia Du Zhong, Achyranthes Niu Xi, Acanthopanax Wu Jia Pi.
ii. Cold-Damp Rheumatism, Morinda Ba Ji Tian with Aconitum Fu Zi, Acanthopanax Wu Jia Pi, Cyathula Niu Xi, Dendrobium Shi Hu, Licorice, Poria Fu Ling, Saposhnikovia Fang Feng. (as in Ba Ji Tang from Wonderful Well-Tried Prescriptions)
iii. Lower Back and Knee pain and weakness, barely able to walk, with Cyathula Niu Xi, Notopterygium Qiang Huo, Cinnamon, Acanthopanax Wu Jia Pi, Eucommia Du Zhong, Ginger Root. (as in Ba Ji Wan, from The Great Peace Sagacious Benevolence Formulary),
6. Osteoporosis, Morinda Bai Ji Tian with Achyranthes Niu Xi, Cornus Shan Zhu Yu
7. Menopausal syndrome with flushing, sweating, irritability, insomnia with Yin and Yang deficiency and deficiency Heat, Morinda Bai Ji Tian with Anemarrhena Zhi Mu, Phellodendron Huang Bai, Epimedium Yin Yang Huo, Dang Gui (as in Er Xian Tang)
8. Dementia, Alzheimer's Diseases, Morinda Bai Ji Tian with Dodder seed (Tu Si Zi) (See research)
9. Beriberi, stir-fried Morinda Bai Ji Tian with stir-fried Rhubarb (Da Huang), form honey pills. (Ben Cao Gang Mu)
Major Formulas:
Bu Shen Gu Chong Wan
Di Huang Yin Zi
Dao Gan Tang
Er Xian Tang
Cautions:
1. Not for Damp-Heat or Heat from Yin deficiency
2. Not for urinary difficulty
Main Preparations used:
1. Not for Damp-Heat or Heat from Yin deficiency
2. Not for urinary difficulty
Main Preparations used:
Click the Tabs above for more information on this Medicin
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Last Updated 01/24
GENERAL / REVIEW:
–Morinda officinalis How. - A comprehensive review of traditional uses, phytochemistry and pharmacology.
–Isolation, phytochemistry, characterization, biological activity, and application of Morinda officinalis How oligosaccharide: a review.
–Monotropein: A comprehensive review of biosynthesis, physicochemical properties, pharmacokinetics, and pharmacology.
–Oligosaccharides from Traditional Chinese Herbal Medicines: A Review of Chemical Diversity and Biological Activities.
–[Chemical constituents of Morinda officinalis How].
PROCESSING:
–[Comparative study on kidney tonifying and yang supporting effects of different processed products of Morinda officinalis].
ANTIOXIDANT:
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
ANTI-INFLAMMATORY:
–Methyl 2-naphthoates with anti-inflammatory activity from Morinda officinalis.
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
–Iridoids with anti-inflammatory effect from the aerial parts of Morinda officinalis How.
–Anti-inflammatory naphthoates and anthraquinones from the roots of Morinda officinalis.
–Iridoid glycosides from Morinda officinalis How. exert anti-inflammatory and anti-arthritic effects through inactivating MAPK and NF-κB signaling pathways.
SLOWS AGING:
–Oligosaccharides from Morinda officinalis Slow the Progress of Aging Mice by Regulating the Key Microbiota-Metabolite Pairs.
MALE SEXUAL FUNCTION:
–Effect of bajijiasu isolated from Morinda officinalis F. C. how on sexual function in male mice and its antioxidant protection of human sperm.
SPERM MOTILITY:
–[Effects of semen Cuscutae, rhizoma Curculiginis, radix Morindae officinalis on human spermatozoan's motility and membrane function in vitro].
NEUROPROTECTIVE:
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
–Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D-Galactose and Aβ 25-35-Induced Rat Model of Alzheimer's Disease.
–Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.
–The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone.
ANTISTRESS:
–Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats.
ANTIDEPRESSANT:
–Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation.
–Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy.
–Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2.
–Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota.
–Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation.
–Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis.
–Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model.
–In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis.
–BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats.
–[Antidepressant active constituents in the roots of Morinda officinalis How].
PTSD:
–The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder.
DEMENTIA / ALZHEIMER'S DISEASE:
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
–Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D-Galactose and Aβ 25-35-Induced Rat Model of Alzheimer's Disease.
–Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer's Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis.
–Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.
–Bioassay-Guided Isolated Compounds from Morinda officinalis Inhibit Alzheimer's Disease Pathologies.
–[Protective effect of oligosaccharides from Morinda officinalis on beta-amyloid-induced dementia rats].
ARTHRITIS:
–Iridoid glycosides from Morinda officinalis How. exert anti-inflammatory and anti-arthritic effects through inactivating MAPK and NF-κB signaling pathways.
–Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice.
–[Effect of Different Processed Products and Extracts of Morinda officinalis Root on Adjuvant-Induced Arthritis in Rats].
OSETOPOROSIS:
–Morinda officinalis polysaccharide promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells via microRNA-210-3p / scavenger receptor class A member 3.
–Molecular mechanism of Achyranthis bidentatae radix and Morindae officinalis radix in osteoporosis therapy: An investigation based on network pharmacology, molecular docking, and molecular dynamics simulations.
–Morinda officinalis polysaccharide attenuates osteoporosis in rats underwent bilateral ovariectomy by suppressing the PGC-1α/PPARγ pathway.
–Morinda officinalis polysaccharide regulates rat bone mesenchymal stem cell osteogenic-adipogenic differentiation in osteoporosis by upregulating miR-21 and activating the PI3K/AKT pathway.
–Network pharmacology-based investigation on the mechanisms of action of Morinda officinalis How. in the treatment of osteoporosis.
DIABETES:
–Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation.
ULCERATIVE COLITIS:
–The Extracts of Morinda officinalis and Its Hairy Roots Attenuate Dextran Sodium Sulfate-Induced Chronic Ulcerative Colitis in Mice by Regulating Inflammation and Lymphocyte Apoptosis.
CANCER:
–Monotropein inhibits colitis associated cancer through VDR/JAK1/STAT1 regulation of macrophage polarization.
–Morinda officinalis How. - A comprehensive review of traditional uses, phytochemistry and pharmacology.
–Isolation, phytochemistry, characterization, biological activity, and application of Morinda officinalis How oligosaccharide: a review.
–Monotropein: A comprehensive review of biosynthesis, physicochemical properties, pharmacokinetics, and pharmacology.
–Oligosaccharides from Traditional Chinese Herbal Medicines: A Review of Chemical Diversity and Biological Activities.
–[Chemical constituents of Morinda officinalis How].
PROCESSING:
–[Comparative study on kidney tonifying and yang supporting effects of different processed products of Morinda officinalis].
ANTIOXIDANT:
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
ANTI-INFLAMMATORY:
–Methyl 2-naphthoates with anti-inflammatory activity from Morinda officinalis.
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
–Iridoids with anti-inflammatory effect from the aerial parts of Morinda officinalis How.
–Anti-inflammatory naphthoates and anthraquinones from the roots of Morinda officinalis.
–Iridoid glycosides from Morinda officinalis How. exert anti-inflammatory and anti-arthritic effects through inactivating MAPK and NF-κB signaling pathways.
SLOWS AGING:
–Oligosaccharides from Morinda officinalis Slow the Progress of Aging Mice by Regulating the Key Microbiota-Metabolite Pairs.
MALE SEXUAL FUNCTION:
–Effect of bajijiasu isolated from Morinda officinalis F. C. how on sexual function in male mice and its antioxidant protection of human sperm.
SPERM MOTILITY:
–[Effects of semen Cuscutae, rhizoma Curculiginis, radix Morindae officinalis on human spermatozoan's motility and membrane function in vitro].
NEUROPROTECTIVE:
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
–Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D-Galactose and Aβ 25-35-Induced Rat Model of Alzheimer's Disease.
–Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.
–The cytoprotective effect of inulin-type hexasaccharide extracted from Morinda officinalis on PC12 cells against the lesion induced by corticosterone.
ANTISTRESS:
–Antistress effect of oligosaccharides extracted from Morinda officinalis in mice and rats.
ANTIDEPRESSANT:
–Inulin-type oligosaccharides of Morinda officinalis exerted antidepressant effects by reducing hippocampal inflammation.
–Morinda officinalis oligosaccharides mitigate depression-like behaviors in hypertension rats by regulating Mfn2-mediated mitophagy.
–Morinda officinalis oligosaccharides mitigate chronic mild stress-induced inflammation and depression-like behaviour by deactivating the MyD88/PI3K pathway via E2F2.
–Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota.
–Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation.
–Efficacy and safety of Morinda officinalis oligosaccharide capsules for depressive disorder: a systematic review and meta-analysis.
–Fructo-oligosaccharides from Morinda officinalis remodeled gut microbiota and alleviated depression features in a stress rat model.
–In Silico Prediction of the Anti-Depression Mechanism of a Herbal Formula (Tiansi Liquid) Containing Morinda officinalis and Cuscuta chinensis.
–BDNF-GSK-3β-β-Catenin Pathway in the mPFC Is Involved in Antidepressant-Like Effects of Morinda officinalis Oligosaccharides in Rats.
–[Antidepressant active constituents in the roots of Morinda officinalis How].
PTSD:
–The inulin-type oligosaccharides extract from morinda officinalis, a traditional Chinese herb, ameliorated behavioral deficits in an animal model of post-traumatic stress disorder.
DEMENTIA / ALZHEIMER'S DISEASE:
–Neuroprotective effects of Morinda officinalis How.: Anti-inflammatory and antioxidant roles in Alzheimer's disease.
–Neuroprotective Effects of OMO within the Hippocampus and Cortex in a D-Galactose and Aβ 25-35-Induced Rat Model of Alzheimer's Disease.
–Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer's Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis.
–Neuroprotective effects of bajijiasu against cognitive impairment induced by amyloid-β in APP/PS1 mice.
–Bioassay-Guided Isolated Compounds from Morinda officinalis Inhibit Alzheimer's Disease Pathologies.
–[Protective effect of oligosaccharides from Morinda officinalis on beta-amyloid-induced dementia rats].
ARTHRITIS:
–Iridoid glycosides from Morinda officinalis How. exert anti-inflammatory and anti-arthritic effects through inactivating MAPK and NF-κB signaling pathways.
–Monotropein attenuates apoptosis and pyroptosis in chondrocytes and alleviates osteoarthritis progression in mice.
–[Effect of Different Processed Products and Extracts of Morinda officinalis Root on Adjuvant-Induced Arthritis in Rats].
OSETOPOROSIS:
–Morinda officinalis polysaccharide promotes the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells via microRNA-210-3p / scavenger receptor class A member 3.
–Molecular mechanism of Achyranthis bidentatae radix and Morindae officinalis radix in osteoporosis therapy: An investigation based on network pharmacology, molecular docking, and molecular dynamics simulations.
–Morinda officinalis polysaccharide attenuates osteoporosis in rats underwent bilateral ovariectomy by suppressing the PGC-1α/PPARγ pathway.
–Morinda officinalis polysaccharide regulates rat bone mesenchymal stem cell osteogenic-adipogenic differentiation in osteoporosis by upregulating miR-21 and activating the PI3K/AKT pathway.
–Network pharmacology-based investigation on the mechanisms of action of Morinda officinalis How. in the treatment of osteoporosis.
DIABETES:
–Effects of Root Extract of Morinda officinalis in Mice with High-Fat-Diet/Streptozotocin-Induced Diabetes and C2C12 Myoblast Differentiation.
ULCERATIVE COLITIS:
–The Extracts of Morinda officinalis and Its Hairy Roots Attenuate Dextran Sodium Sulfate-Induced Chronic Ulcerative Colitis in Mice by Regulating Inflammation and Lymphocyte Apoptosis.
CANCER:
–Monotropein inhibits colitis associated cancer through VDR/JAK1/STAT1 regulation of macrophage polarization.