Sarcandra, Zhong Jie Feng 肿节风
Glabrous Sarcandra
Zhong Jie Feng, Jiu Jie Cha (TCM)
Botanical name:
Sarcandra glabra (syn. Chloranthus glaber, Ardisia japonica)
Parts used:
Herb
Temperature & Taste:
Warm, dry. Bitter, Pungent
Uses:
1. Clears Heat from the Blood:
-Purpura from Blood heat
-Thrombocytopenic Purpura
-Eczema, Psoriasis
-Phlegmon
2. Clears Heat and Toxin:
-Red and Swollen Gums, Mouth or Throat, Tonsillitis, Gingivitis
-Sores, Boils, Carbuncles, Abscess
-Dysentery, Appendicitis
-Cholecystitis
-Cellulitis
-Pneumonia
-topically as a wash for Ulcerated Wounds
3. Move the Blood, Clear Stasis:
-Trauma and Bruising, Fracture
-Dysmenorrhea
-Postpartum blood stasis abdominal pain
-Tumors, Cancer (Gastric, Pancreatic, Liver, Esophagel), Leukemia
4. Clears Wind-Damp, Opens the Channels:
-Wind-Damp joint and muscle pain
-Numbness of the limbs
Dose:
Decoction: 9–15 grams (up to 30 grams for Cancer)
It can also be soaked in wine for Blood stasis, Bruises, Fractures or Wind-Damp Arthritic pain
Topically, it can be beaten and applied
Comment:
1. The medicinal use of this plant did not appear in China until 1711 (Sheng Cao Yao Xing Bei Yao)
2. In China, concentrated extracts made into tablets and injections of Sarcandra are used in Cancer therapy and for other uses.
3. Locals of Jiangxi province, China, combined Sarcandra with Houttuynia, Rice, Sesame and salt to make a drink.
Main Combinations:
1. Cough, Bronchitis, Sarcandra with Houttuynia Yu Xing Cao.
2. Psoriasis, Sarcandra with Turmeric, China root (Tu Fu Ling), Prunus Wu Mei, Paeonia Bai Shao (This is called PSORI-CM02 and has been studied and found effective)
3. Stomach Cancer: Sarcandra (15 grams), decoct and drink. (“Guizhou Herbal Medicine“)
Major Formulas:
Cautions:
1. Not used in Pregnancy
2. Not used in Yin-deficient Heat
Main Preparations used:
GENERAL / REVIEW
–The Traditional Uses, Phytochemistry and Pharmacology of Sarcandra glabra (Thunb.) Nakai, a Chinese Herb With Potential for Development:
–A review of botany, ethnomedicine, phytochemistry, pharmacology and toxicology of Sarcandra species.
–A comprehensive review on the chemical constituents, sesquiterpenoid biosynthesis and biological activities of Sarcandra glabra.
–[Research progress on chemical constituents and biological activities of Sarcandra glabra].
–The Traditional Uses, Phytochemistry and Pharmacology of Sarcandra glabra (Thunb.) Nakai, a Chinese Herb With Potential for Development: Review.
–[Chemical constituents from Sarcandra glabra].
EXTRACTION
–[Comparison study of different extraction methods of Sarcandra glabra].
ANTI-BACTERIAL
–[Studies on chemical constituents and antibacterial activity from n-butanol extract of Sarcandra glabra].
–[Studies on chemical constituents of Sarcandra glabra].
ANTI-VIRAL
–Dual Inhibition of HIV-1 and Cathepsin L Proteases by Sarcandra glabra.
INFLUENZA
–Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice
ANTI-OXIDANT
–Sarcandra glabra (Caoshanhu) protects mesenchymal stem cells from oxidative stress: a bioevaluation and mechanistic chemistry.
–Hypoglycemic, hypolipidemic and antioxidant effects of Sarcandra glabra polysaccharide in type 2 diabetic mice.
–Characterization and antioxidant activity of a polysaccharide extracted from Sarcandra glabra.
ANTI-INFLAMMATORY
–Structurally diverse sesquiterpenoids from Sarcandra glabra and their anti-inflammatory activities.
–Anti-Inflammatory Lindenane Sesquiterpenoid Dimers from the Roots of Sarcandra glabra
–Dimeric sesquiterpenoids and anti-inflammatory constituents of Sarcandra glabra.
–Anti-inflammatory effects of a SERP 30 polysaccharide from the residue of Sarcandra glabra against lipopolysaccharide-induced acute respiratory distress syndrome in mice.
–The anti-inflammatory activity by suppressing the TRAF6/MAPKs pathway of trishizukaol a from Sarcandra glabra.
–Sarcanolides C-E: three new lindenane sesquiterpenoid dimers with anti-inflammatory activities from Sarcandra glabra.
–Shizukaol A exerts anti-inflammatory effect by regulating HMGB1/Nrf2/HO-1 pathway.
–Isofraxidin ameliorated influenza viral inflammation in rodents via inhibiting platelet aggregation.
–Anti-inflammatory Principles from Sarcandra glabra.
–Sesquiterpenoids from the seeds of Sarcandra glabra and the potential anti-inflammatory effects.
–Systematic Analysis of Absorbed Anti-Inflammatory Constituents and Metabolites of Sarcandra glabra in Rat Plasma Using Ultra-High-Pressure Liquid Chromatography Coupled with Linear Trap Quadrupole Orbitrap Mass Spectrometry.
–A new coumarin isolated from Sarcandra glabra as potential anti-inflammatory agent.
IMMUNOMODULATORY
–[Effects of Sarcandra glabra extract on immune activity in restraint stress mice].
ACUTE LUNG INJURY
–Sarcandra glabra combined with lycopene protect rats from lipopolysaccharide induced acute lung injury via reducing inflammatory response.
–Protective effects of Isofraxidin against lipopolysaccharide-induced acute lung injury in mice.
ANALGESIC
–Sarcandra glabra (Thunb.) Nakai relieves pain behavior by inhibiting Na(V)1.7 channels.
INHIBITS ACETYLCHOLINESTERASE
–Coumarins from Sarcandra glabra (Thunb.) Nakai and Acetylcholinesterase Inhibiting Activity.
ANTI-ULCER
–Assessment of the Potential of Sarcandra glabra (Thunb.) Nakai. in Treating Ethanol-Induced Gastric Ulcer in Rats Based on Metabolomics and Network Analysis.
ANTI NEUROINFLAMMATORY
–Sarglamides A-E, Indolidinoid-Monoterpenoid Hybrids with Anti-neuroinflammatory Activity from a Sarcandra Species.
ANTI-THROMBOCYTOPENIA
–Exploring the therapeutic potential of extractions of total flavonoids from Sarcandra Glabra in immune thrombocytopenia: A metabolomic and network pharmacology approach.
–[The study on effect of Sarcandra glabra on prevention and treatment of thrombocytopenia by chemotherapy].
HEPATO-PROTECTIVE
–Hepatoprotective sesquiterpene glycosides from Sarcandra glabra.
HYPOGLYCEMIC
–Hypoglycemic, hypolipidemic and antioxidant effects of Sarcandra glabra polysaccharide in type 2 diabetic mice.
DIABETIC ENCEPHALOPATHY
–Polysaccharide extracted from Sarcandra glabra residue attenuate cognitive impairment by regulating gut microbiota in diabetic mice.
ULCERATIVE COLITIS
–Sarcandra glabra (Thunb.) Nakai alleviates DSS-induced ulcerative colitis by promoting restitution, restoring barrier function, and modulating IL-17/Notch1/FoxP3 pathway in intestinal cells.
OSTEOARTHRITIS
–Astilbin prevents osteoarthritis development through the TLR4/MD-2 pathway.
ANTI-TUMOR
–A purified acidic polysaccharide from Sarcandra glabra as vaccine adjuvant to enhance anti-tumor effect of cancer vaccine.
–Antitumor activity of caffeic acid 3,4-dihydroxyphenethyl ester and its pharmacokinetic and metabolic properties.
CANCER
–Network Pharmacology‐Based Study on the Active Component and Mechanism of the Anti-Gastric-Cancer Effect of Herba Sarcandrae
–[Effect of rosmarinic acid from Sarcandra glabra in inhibiting proliferation and migration and inducing apoptosis of MDA-MB-231 cells via regulation of expressions of Bcl-2 and Bax].
–Caffeic acid 3,4-dihydroxy-phenethyl ester induces cancer cell senescence by suppressing twist expression.
LEUKEMIA
–Antileukemic effect of caffeic acid 3,4-dihydroxyphenetyl ester. Evidences for its mechanisms of action.
LIVER
–Uvangoletin, extracted from Sarcandra glabra, exerts anticancer activity by inducing autophagy and apoptosis and inhibiting invasion and migration on hepatocellular carcinoma cells.
LUNG
–S. glabra exerts anti-lung cancer effects by inducing ferroptosis and anticancer immunity.
NASOPHARYNGEAL
–[Clinical observation of sarcandra glabra combined chemoradiotherapy for treating patients with local advanced nasopharyngeal carcinoma].
–[Study on the apoptosis of nasopharyngeal carcinoma cell line administrated with Sarcandra glabra extracts in vivo and its mechanism].
OSTEOSARCOMA
–SGP-2, an acidic polysaccharide from Sarcandra glabra, inhibits proliferation and migration of human osteosarcoma cells.
PANCREATIC
–Revealing the multi-target compounds of Sarcandra glabra identification and inhibition of novel target genes for the treatment of pancreatic cancer.
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