Prunella, Self-heal, Xia Ku Cao 夏枯草
Brunella; Also called Consolida minor
Xia Ku Cao (TCM)


Ortus Sanitatis, Meydenbach, 1491

New Kreuterbuch, Matthiolus, 1563

Kurtzes Handtbuchlein, Ryff, 1599

Dietrich, Flora regni borussici, 1834
Botanical name:
Prunella vulgaris
Prunella hispida is also used in parts of China.
Parts used:
Flowering tops; Herb
Temperature & Taste:
Cool, dry. (Warm in the West). Slightly Sweet, Bitter, Pungent
Bitter, Cleansing, Binding
Classifications:
2D ATTENUATERS OF CONGEALED BLOOD
2T. GLUTINATE
TCM:
B. Clear Strong Heat or Fire
Uses:
1. Clears Liver Heat (TCM, West):
-red, swollen, painful eyes
-Headache, Dizziness, Convulsions, Vertigo, Epilepsy
-Hepatitis
-Hypertension; it has also been regarded as effective for Hypotension
-Hyperthyroidism
-“Miraculously effective in relieving pain in the Eyeballs, which is aggravated at Night”. (Luo Quan Shan)
-“Long term use mankes one feel Happy”. (Shen Nong Ben Cao)
2. Clears Heat and Poison:
-Toxic Sores, Abscesses, Carbuncles
-“the bites of Mad Dogs and Venomous beasts” (Culpeper)
-also taken to prevent Infection during epidemics including Measles
-“Quinsey [Tonsillitis], sores and ulcers of the mouth and jaws”. (Salmon)
-Dysentery (TCM)
-Viral infections including Herpes, Glandular Fever, Mumps, HIV etc.
3. Clears Heat and Poison, Resolves Masses:
-phlegm and heat-type Scrofula, Goiter, Lymphadenitis, Swollen Glands in the neck, and various other nodes and swellings
-used as a stand-alone herb for Scrofula, including those that have ruptured or ulcerated
-special for Mastitis, Abscesses, Tumors and Cancer of the Breast
-other Tumors and Cancers including Lymphoma
-“It dissolves hard masses, disperses Goiter and accumulation of Qi”. (Shen Nong Ben Cao)
4. Clears Heat, Clears Stasis, Promotes Healing:
-A valuable Vulnerary (Wound herb); long used internally or externally for all sorts of Wounds, Bruises, internal Bleeding
-internal or external Ulcers, including Ulcers of the mouth, anus, vagina, and Lungs.
-Fractures and Dislocations (int. & ext.)
-“used chiefly in Wounds of the Lungs”. (Schroder)‘
-“the Essence hereof taken inwardly causes all wounds inward and outwardly to heal”. (Salmon)
-“eases such as have any broken Bone in their Body, or any Dislocation of a Joint, both used inwardly and applied outwardly”. (The Compleat Herbal, Tournefort, 1719)
5. Moves the Blood, Clears Blood Stasis:
-Amenorrhea, sluggish Menstruation
-Postpartum Hemorrhage
-“Expels a dead child” (Culpeper)
-“Dissolves congealed blood” (Salmon)
-“drives away Apoplexy” taken with Vinegar. (Dorsetn, 1540)
-“the herb is also good for Tonifying the Blood”. (Zhe Zhen Heng)
6. Clears Heat and Damp, Promotes Urine:
-Difficult Urination and Edema.
-has been used for Bedwetting
-“helps all joint aches” and “is excellent for all griefs of the Sinews” (Culpeper); Gout and Arthritis (TCM, West).
-In Europe it has also been used for Jaundice, Gravel and Stones.
-“Treats swollen feet and Arthralgia due to pathogenic Damp”. (Shen Nong Ben Cao)
-“it expels evil humors through the lower parts”. (Dorsetn, 1540)
7. Clears Heat, Stops Cough:
-“A Great Pectoral” (Salmon)
-heat-type Cough and Lung disease
8. Kills Worms.
9. Externally:
-topically for all inflammations (plaster)
-topically to minor skin Sores, Infections and Rashes
-used for various Wounds and Ulcers (plaster, or fresh herbs beaten and applied)
-“great Efficacy in fresh Wounds, or in putrid Ulcers, either of the Fundament, or of the Privy Parts”. (The Compleat Herbal, Tournefort, 1719)
-topically applied to the bites of Rabid Dogs and other venomous Bites. (plaster, or fresh herb beaten and applied)
-applied to Cramps, Pain and Spasms of the Sinews and Tendons. (the ointment or plaster is applied topically)
-as a mouth wash or gargle for all sores and inflammations of the Mouth, Gums and Throat.
Dose:
It is drank as tea during the summer to clear heat.
DECOCTION or LONG INFUSION: 6–15 grams, up to 30 grams in severe cases (20–60 grams fresh). Around 45 grams is the normal maximum daily dose of the dried herb, which is built up to and used only if needed;
POWDER: 1–4 grams
TINCTURE (1:5): 2–5 mls;
FRESH JUICE: 5 drops up to 10 mls. are added to a glass of warm water, and this is taken as a dose.
SYRUP of the FRESH JUICE made with HONEY: taken in teaspoonful doses
Substitute:
1. Bugle (Bugle and Self Heal were previously regarded as one herb in Europe)
2. Prunella is a substitute for Stoechas in Unani medicine.
Comment:
Prunella is a valuable medicine, used in East and West, with several important spheres of activity:
1. Liver Heat
2. Hyperthyroidism; Scrofula and nodules of the neck; Cancer
3. Trauma; Wounds; congealed Blood
4. Various Viral diseases
Despite the fact that it is viewed as Cold in TCM, Prunella is drunk as a health beverage in parts of China.
Main Combinations:
1. Liver Heat:
i. Self Heal with Dandelion, Peppermint
ii. Self Heal with Gentian, Scutellaria Huang Qin (TCM)
iii. Self Heal with headache, dizziness, red and sore eyes, with Cyperus rotundus and Licorice (Xia Ku Cao San from the Zhang Shi Yi Tong [Comprehensive Medicine according to Master Zhang]).
2. Hyperthyroidism, Liver Heat:
i. Self Heal with Balm
ii. from excess Liver heat, Self Heal with Scutellaria Huang Qin, Gardenia Zhi Zi, Gentiana Long Dan Cao
3. Scrofula, Lymphatic swelling:
i. Self Heal with Figwort
ii. Self Heal with Kelp, Licorice (as in Decoction of Self Heal and Kelp)
iii. Self Heal with Hyssop and Peppermint (as in Decoction of Self Heal)
iv. Self Heal with Balm, Walnut leaf, St. John’s wort, Calendulav. Self Heal with Kelp and Figwort (Xuan Shen) (TCM)
vi. Self Heal with Fritillaria Bei Mu, Cyperus rotundus (Xiang Fu) for Phlegm-heat with Liver Qi stagnation (Xia Ku Cao Tang from Wai Ke Zheng Zong [True Lineage of External Medicine]).
4. Goiter, Self Heal, Oyster shell (Mu Li), Fritillaria Bei Mu
5. Hypertension:
i. Self Heal with Mistletoe, Peony
ii. Self Heal with Hawthorn, Balm
6. Sore, red eyes:
i. “Soak Prunella Xia Ku Cao in sugared water overnight. Use this to treat Eye Pain”. (Li Shi Zhen)
ii. Self Heal with Eyebright
iii. Self Heal with Goji berries and Chrysanthemum (Ju Hua)
iv. Self Heal with Chrysanthemum (Ju Hua) and Cassia seed Jue Ming Zi
v. Redness, tearing, pain of the eyeballs, photophobia, Self Heal with Cyperus rotundus (Bu Gan San from Jian Yao Ji Zhong Fang [Brief Prescriptions that Aid All People])
vi. Liver deficient Eye pain, Self Heal, Cyperus rotundus, Licorice
7. Deviation of the Eyes and Mouth (ie. Post Stroke), Self Heal, Saposhnikovia Fang Feng, Arisaema prepared with Bile (Dan Nan Xing) (from Southern Yunnan Materia Medica)
8. Sore and Swollen Throat, Tonsilitis:
i. decoct 60–90 grams of fresh Self Heal, decoct and drink over the day. (Compilation of Simple Prescriptions of Herbal Medicine and Herbal Medicine)
ii. Self Heal with Sage, Tormentil, Marshmallow, Elder flower, Licorice (Gazophylacium Medico-Physicum, Woyts, 1746)
9. Cough: “The herb itself, boiled and tempered with almond oil and the juice of pomegranates, and taken, cures a hot cough”. (Dorsetn, 1540)
10. Mastitis, Breast Lumps:
i. Self Heal, Dandelion (Pu Gong Ying) (equal parts). decocted in wine or made into pills
ii. Self Heal, Bupleurum Chai Hu, Fritillaria Bei Mu, Paeonia rubra Chi Shao Yao
11. Bleeding, take 1 teaspoonful of Self Heal powder with rice soup.
12. Leukorrhea with Blood, take 6 grams of the powder of Self Heal
13. Bedwetting, Self Heal with Speedwell (Veronica)
Externally:
14. Wound including Knife wounds, chew fresh Self Heal and apply
15. Non-healing Wounds, Self Heal, Lady’s Mantle, Sanicle, Tormentil (Herbarium Horstianum, 1630)
16. Wash for Sores and skin inflammations, Self Heal with Honeysuckle flower (Jin Yin Hua) or Camomile
17. A wash for Wounds and Ulcers, Self Heal with Bugle and Sanicle (Culpeper)
18. Fractures, combine Self Heal with Comfrey, both internally and topically
19. Plaster for Dislocations and Trauma of the Joints, Self Heal with Hollyhock root, Frankincense, Myrrh, Shilajit and Turpentine, made into a plaster with Suet and Oil (The Compleat Bone-setter, Turner, 1656)
20. Headache from Heat and inflammation:
i. “The juice of this herb, tempered with rose water, applied to the head, soothes the pain”. (Dorsetn, 1540)
ii. Self Heal juice with Vinegar of Roses, applied topically. (Herbarium Horstianum, 1630)
Major Formulas:
Decoction of Self Heal
Decoction of Self Heal and Kelp
Decoction of Timaei (modified)
Powder for Cancerous Ulcers (Gabelhover)
Plaster for Dislocations
Cautions:
Generally Safe.
1. In TCM it is not used for marked weakness (Qi deficiency).
2. It may lower Thyroid function and aggravate Hypothyroid conditions.
Main Preparations used:
Distilled Water of the Herb, Juice, Conserve of the Flowers
1. Conserve of the Flowers:
i. fresh Flower (1 part), Sugar (2 parts). Beat.
2. Juice of Self Heal:
i. Fresh Self Heal; bruise in a stone mortar, sprinkling with a little water; express strongly. Set aside the juice, then decant the clear liquid, preserving in bottles, adding to every pound, 1 dram of alcohol. (Pharmacopoeia Herbipolitania, 1796)
3. Syrup of Self Heal:
i. Juice of Self Heal depurated and reduced to half by slow evaporation (9 oz.), White Sugar (16 oz.). Dissolve. (Pharmacopoeia Wirtembergica, 1798)
Click the above Tabs for more information on this medicine
ANTIBACTERIAL
Broad-spectrum Antibacterial: effective against Shigella, Typhoid Bacillus, Vibrio cholerae, Escherichia coli, Proteus, Pseudomonas aeruginosa, Staphylococcus, Streptococcus etc.
–Antimicrobial activity of Prunella Vulgaris extracts against multi-drug resistant Escherichia Coli from patients of urinary tract infection
ANTIOXIDANT
–In vitro antioxidant and anticancer effects of solvent fractions from prunella vulgaris var. lilacina
–Antioxidant Activities of Total Phenols of Prunella vulgaris L. in Vitro and in Tumor-bearing Mice
ANTI-VIRAL
–Identification and evaluation of the inhibitory effect of Prunella vulgaris extract on SARS-coronavirus 2 virus entry
–Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.
–Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris
–Characterization of the inhibitory effect of an extract of Prunella vulgaris on Ebola virus glycoprotein (GP)-mediated virus entry and infection
–Potential of selected Lamiaceae plants in anti(retro)viral therapy
IMMUNOMODULATORY
–Effects of Prunella vulgaris on the Mice Immune Function
HEPATOPROTECTIVE
–Invivo hepatoprotective potential of extracts obtained from floral spikes of Prunella vulgaris L
THYROID NODULES
–Safety and efficacy of Prunella vulgaris preparation in adjuvant treatment of thyroid nodules: A meta-analysis
THYROIDITIS
–Analysis of the Molecular Mechanisms of the Effects of Prunella vulgaris against Subacute Thyroiditis Based on Network Pharmacology
–Initial treatment combined with Prunella vulgaris reduced prednisolone consumption for patients with subacute thyroiditis
–Prunella vulgaris L. Attenuates Experimental Autoimmune Thyroiditis by Inhibiting HMGB1/TLR9 Signaling
HASHIMOTO’S THYROIDITIS
–Network Pharmacology to Explore the Molecular Mechanisms of Prunella vulgaris for Treating Hashimoto’s Thyroiditis
–Innate Immune-Modulatory Activity of Prunella vulgaris in Thyrocytes Functions as a Potential Mechanism for Treating Hashimoto’s Thyroiditis
–Effect of large dosage of Prunella on Hashimoto’s thyroiditis: A protocol of systematic review and meta-analysis of randomized clinical trials
DIABETES
–Study on the Mechanism of Prunella Vulgaris L on Diabetes Mellitus Complicated with Hypertension Based on Network Pharmacology and Molecular Docking Analyses
HYPERTENSION
–Anti-Hypertensive Herbs and Their Mechanisms of Action: Part II
VASCULITIS
–Prunella vulgaris Suppresses HG-Induced Vascular Inflammation via Nrf2/HO-1/eNOS Activation
–The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells
ANTI-ESTROGENIC
–Characterization of Antiestrogenic Activity of the Chinese Herb, Prunella vulgaris, Using In Vitro and In Vivo (Mouse Xenograft) Models
CANCER
–In vitro antioxidant and anticancer effects of solvent fractions from prunella vulgaris var. lilacina
BREAST
–Oral Administration of Prunella vulgaris L Improves the Effect of Taxane on Preventing the Progression of Breast Cancer and Reduces Its Side Effects
COLORECTAL
–Spica Prunellae Extract Enhances Fluorouracil Sensitivity of 5-Fluorouracil-Resistant Human Colon Carcinoma HCT-8/5-FU Cells via TOP2α and miR-494
GASTRIC
–Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo
LUNG
–Identification of Two Polysaccharides from Prunella vulgaris L. and Evaluation on Their Anti-Lung Adenocarcinoma Activity
–Combination of Active Components Enhances the Efficacy of Prunella in Prevention and Treatment of Lung Cancer
LYMPHOMA
–A Study on Inhibitory Effect of Spica Prunellae Extract on T Lymphoma Cell EL-4 Tumour
THYROID
–The Chinese herb Prunella vulgaris promotes apoptosis in human well-differentiated thyroid carcinoma cells via the B-cell lymphoma-2/Bcl-2-associated X protein/caspase-3 signaling pathway
–The Antitumour Effect of Prunella vulgaris Extract on Thyroid Cancer Cells In Vitro and In Vivo
UTERINE
–Characterization and anti-uterine tumor effect of extract from Prunella vulgaris L.
AGING
–Prunella vulgaris L. Exerts a Protective Effect Against Extrinsic Aging Through NF-κB, MAPKs, AP-1, and TGF-β/Smad Signaling Pathways in UVB-Aged Normal Human Dermal Fibroblasts
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