Inonotus obliquus, Chaga
Hua Jie Kong Jun 桦褐孔菌 (TCM)
Kabanoatanake (Japan)
Botanical name:
Inonotus obliquus
Parts used:
Fungii, traditionally only from the Birch tree
Typically found on Birch, Elm and Alder trees
Temperature & Taste:
Neutral. slightly Sweet and Bitter
Constituents:
Polysaccharides
Phenols (high levels)
Betulinic acid (especially when derived from Birch tree but also found in the mycelium when grown on rice.)
Uses:
1. Clears Damp, Resolves Masses
-Anti-tumor
-effective against Cancers of the Liver, Gastric, Colon, Lung, Breast, Prostate, Esophagus
2. Strengthens Spleen, Benefits Qi:
-Indigestion, Nausea, Vomiting,
-chronic gastroduodenal dysfunction
-beneficial effect on metabolism (Russian research)
-increases immunity
-Diabetes
-Anti-aging
3. Clears Stomach Heat:
-Diarrhea, Colitis, chronic Gastritis
-Gastric and Duodenal Ulcers
-Polyps of the Stomach and Bowels
4. Clears Liver Heat:
-Hepatitis
-Hypertension
-Psoriasis, Eczema and other skin diseases
-effective against allergies
-Anti-viral inc. AIDS
-Nephritis
5. Nourishes Heart, Calms the Mind:
-Neurasthenia, Insomnia
-beneficial effect on Nerves and Brain
Dose:
Decoction: 3–9 grams
Fluid Extract (1:1 in 45% alcohol): 2–8 mls
Powder: 2–6 grams
Comment:
In Russia an extract is prepared and sold under the name Befungin. It is used for its anti-cancer and immunostimulating effects, for chronic inflammations of the digestive system, for skin diseases etc.
Main Combinations:
Typically used alone although more recently it is often combined with other medicinal fungii.
Cautions:
None noted
Main Preparations used:
Click the above Tabs for more information on this medicine
GENERAL
– Review on Chaga Medicinal Mushroom, Inonotus obliquus (Higher Basidiomycetes): Realm of Medicinal Applications
– Progress of research on Inonotus obliquus
– Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal “mushroom”
– An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus
– Chemical Constituents from Inonotus obliquus and Their Biological Activities
– Chemical constituents from the sclerotia of Inonotus obliquus
– Analysis of aqueous extract of Inonotus obliquus
– Effect of steam treatment on soluble phenolic content and antioxidant activity of the Chaga mushroom (Inonotus obliquus)
– Chemical Constituents of Inonotus obliquus ¶.: Triterpene and Steroids from Cultured Mycelia
– Chemical analysis and antioxidant activity of polysaccharides extracted from Inonotus obliquus sclerotia
– Triterpenoids, steroids, and a new sesquiterpen from Inonotus obliquus
ANTIOXIDANT:
– Antioxidant effect of Inonotus obliquus
– New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus
– Chemical modification and antioxidant activities of polysaccharide from mushroom Inonotus obliquus
– Antioxidative Properties of Crude Polysaccharides from Inonotus obliquus
– Antioxidant activities of five polysaccharides from Inonotus obliquus
– Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus
– Antioxidant activities of extracts and subfractions from Inonotus Obliquus
– Anti-Oxidant and Anti-Inflammatory Activities of Inonotus obliquus and Germinated Brown Rice Extracts
– Inonotus obliquus Protects against Oxidative Stress-Induced Apoptosis and Premature Senescence
ANTI-VIRAL:
– Identification of Inonotus obliquus polysaccharide with broad-spectrum antiviral activity against multi-feline viruses
HEPATOPROTECTIVE:
– The polysaccharide from Inonotus obliquus protects mice from Toxoplasma gondii-induced liver injury
RENAL PROTECTIVE EFFECTS:
– Renal Protective Effects of Low Molecular Weight of Inonotus obliquus Polysaccharide (LIOP) on HFD/STZ-Induced Nephropathy in Mice
ANTI-INFLAMMATORY:
– Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus
– In vivo and in vitro anti-inflammatory and anti-nociceptive effects of the methanol extract of Inonotus obliquus
– Anti-inflammatory effect of Inonotus obliquus, Polygala senega L., and Viburnum trilobum in a cell screening assay
– Ethanol Extract of Inonotus obliquus Inhibits Lipopolysaccharide-Induced Inflammation in RAW 264.7 Macrophage Cells
– Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate
– Inonotus obliquus attenuates histamine-induced microvascular inflammation
INHIBITS PLATELET AGGREGATION:
– Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus
IMMUNE-STIMULATING / IMMUNOMODULATORY:
– Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus
– Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus
– Phenolic compounds from Inonotus obliquus and their immune stimulating effects
– Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus
– Immunostimulating Activity by Polysaccharides Isolated from Fruiting Body of Inonotus obliquus
REGULATES GUT MICROBIOME:
– Inonotus obliquus polysaccharide regulates gut microbiota of chronic pancreatitis in mice
ANTI-CANCER / ANTI-TUMOR
– Anti-cancer effect and structural characterization of endo-polysaccharide from cultivated mycelia of Inonotus obliquus
– Anti-inflammatory and anticancer activities of extracts and compounds from the mushroom Inonotus obliquus
– Antitumor and immunomodulatory activity of water-soluble polysaccharide from Inonotus obliquus
– Identification of Inonotus obliquus and Analysis of Antioxidation and Antitumor Activities of Polysaccharides
– Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells
– Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT‐29 human colon cancer cells
– Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity
– Triterpenoids from Inonotus obliquus and their antitumor activities
– Chemical composition and antitumor activity of polysaccharide from Inonotus obliquus
– Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells
– Ergosterol peroxide from Chaga mushroom (Inonotus obliquus) exhibits anti-cancer activity
– Production of antioxidant and antitumor metabolites by submerged cultures of Inonotus obliquus cocultured with Phellinus punctatus
– Effects of inotodiol extracts from Inonotus obliquus on proliferation cycle and apoptotic gene of human lung adenocarcinoma cell line A549
– Cancer Cell Cytotoxicity of Extracts and Small Phenolic Compounds from Chaga [Inonotus obliquus
– Chaga (Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B)
– Continuous intake of the Chaga mushroom (Inonotus obliquus) aqueous extract suppresses cancer progression and maintains body temperature in mice
– Ethanol extract of Innotus obliquus (Chaga mushroom) induces G1 cell cycle arrest in HT-29 human colon cancer cells
– Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells
– Inhibitory and Acceleratory Effects of Inonotus obliquus on Tyrosinase Activity and Melanin Formation in B16 Melanoma Cells
ANTI-MUTAGENIC:
– Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract
ANTI-DIABETES:
– Antitumor and Hypoglycemic Activities of Polysaccharides from the Sclerotia and Mycelia of Inonotus obliquus
– Antihyperglycemic and antilipidperoxidative effects of dry matter of culture broth of Inonotus obliquus in submerged culture on normal and alloxan-diabetes mice
– Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus
– Anti-diabetic effects of Inonotus obliquus polysaccharides in streptozotocin-induced type 2 diabetic mice
– Anti-diabetic effects of Inonotus obliquus polysaccharides-chromium (III) complex in type 2 diabetic mice and its sub-acute toxicity evaluation in normal mice
– Antidiabetic activities of polysaccharides separated from Inonotus obliquus via the modulation of oxidative stress in mice with streptozotocin-induced diabetes
– Chemical Characterization and Hypoglycaemic Activities In Vitro of Two Polysaccharides from Inonotus obliquus by Submerged Culture
PSORIASIS:
–Russian research reported 76% cure rate and a further 16% improvement over a 9–12-week treatment period. (Medicinal Mushrooms a Clinical Guide – 2nd Ed., Powell, 2014)
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