Gastric Cancer

Gastric Cancer is a Cancer forming in the lining of the Stomach. It is the 5th most common cancer in the developed world and is the most common Gastrointestinal Cancer.

Initially there is often no symptoms. As the tumor progresses, Indigestion, Stomach discomfort and pain, bloating,. heartburn and nausea may appear. Feeling full after eating a small amount of food is also common.

Causes

Chronic Helicobacter pylori infection has been associated with greater increase of Gastric Cancer and is believed to be a contributing reason why China accounts for 40% of world Gastric Cancer cases.

Treatment

When found early, surgery to remove the Tumor is usually performed, along with Chemo- and Radiotherapy.
In advanced Gastric Cancer, the combination of Chinese Herbal Medicine in combination with Oxaliplatin had a 35% increase in effectiveness (see here).

Special Formula

Stomach Cancer
    Hedyotis Bai Hua She She Cao   2 oz.
    Roots of Bulrush                            1 oz.
    Fried ginger (Pao Jiang)               3 grams
    Scutellaria Ban Zhi Lian             15 grams
    Gardenia Zhi Zi                              9 grams
This is decocted. (Barefoot Doctors Manual)

Jian Pi Yang Wei Decoction
    Astragalus Huang Qi
    Codonopsis Dang Shen
    Atractylodes Bai Zhu
    Angelica Dang Gui
    Paeonia Bai Shao
    Citrus Chen Pi
    Ginger processed Pinellia (Jiang Ban Xia)
    Sparganium San Leng
    Zedoary (E Zhu)
    Salvia Dan Shen
    Hedyotis Bai Hua She She Cao
    Licorice
This formula was developed by an expert in Gastric Cancer treatment. In a study of 489 cases of Gastric Cancer followed up for 8 years, it was shown to reduce recurrence in stage II and III cancers by 32% compared to chemotherapy alone. It was also found to be synergistic with 5-Fu. (See Research here)

Cancer of the esophagus, stomach and colon: 
    Dioscorea bulbifera Huang Yao Zi 
    Hedyotis Bai Hua She She Cao    60 grams ea.
    Sophora Shan Dou Gen
    Patrinia Bai Jiang Cao 
    Dictamnus Bai Xian Pi 
    Self Heal (Xia Ku Cao)                    120 grams ea.
Powder, mix with honey to make pills. Dose: 4 to 6 pills daily. (Chen & Chen)

Si Chong Formula
    Earthworm (Di Long)
    Scorpion (Quan Xie)
    Centipede (Wu Gong)
    Wingless Cockroach (Tu Bie Chong)
This has been studied.

Late-stage Gastric Cancer and Esophageal Cancer:
    Toad Venom
    Bezoar (artificial)
    Lonicera Jin Yin Hua
    Centipede (Wu Gong)
    Dandelion (Pu Gong Ying)
    Scutellaria barbata Ban Zhi Lian
    Black Nightshade (Long Kui)
    Pearl
    Rhubarb (Da Huang)
    Olibanum
    Myrrh
    Corydalis Yan Hu Suo
    Safflower (Hong Hua)
    Pinellia ginger-processed Ban Xia
    Codonopsis Dang Shen
    Astragalus Huang Qi
    Amomum Sha Ren
(as in Jin Pu Jiao Nang of the Chinese Pharmacopoeia)
Side Effects of Chemotherapy

Ban Xia Xie Xin Decoction
    Pinellia Ban Xia
    Scutellaria Huang Qin
    Ginseng
    Coptis Huang Lian
    Licorice
    Ginger (Gan Jiang)
    Jujube (Da Zao)
Attenuate chemotherapy-induced gastrointestinal toxicity and mucositis in Gastric and Colorectal Cancer patients. (See here)

Zhi Yin Hua Tan
    Lily bulb (Bai He)
    Pinellia Ban Xia
    Hedyotis Bai Hua She She Cao  
This has been studied and found useful in Gastric Cancer. (See here)

Research:

1. Multidrug Resistance of Gastric Cancer: The Mechanisms and Chinese Medicine Reversal Agents
2. The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies
3. Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression
Basil
–An In Vitro Anti-Cancer Activity of Ocimum tenuiflorum Essential Oil by Inducing Apoptosis in Human Gastric Cancer Cell Line.
Cannabis
–Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
–Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells
Costus:
–Saussurea lappa induces G2-growth arrest and apoptosis in AGS gastric cancer cells.
–Dehydrocostus lactone suppresses gastric cancer progression by targeting ACLY to inhibit fatty acid synthesis and autophagic flux.
Crocus:
–Crocin triggers the apoptosis through increasing the Bax/Bcl-2 ratio and caspase activation in human gastric adenocarcinoma, AGS, cells.
–Anticancer effects of crocetin in both human adenocarcinoma gastric cancer cells and rat model of gastric cancer.
Ginger
–Coptis chinensis and dried ginger herb combination inhibits gastric tumor growth by interfering with glucose metabolism via LDHA and SLC2A1.
Hedyotis:
–Network pharmacology, bioinformatics, and experimental validation to identify the role of Hedyotis diffusa willd against gastric cancer through the activation of the endoplasmic reticulum stress.
–Ziyin Huatan Recipe, a Chinese herbal compound, inhibits migration and invasion of gastric cancer by upregulating RUNX3 expression.
–[Effects of hedyotis diffusa on mitochondrial membrane potential and expressions of apoptosis-related genes in human gastric cancer cell line MNK-45].
–Network Pharmacology-Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer.
–Anticancer effect of 2,7-dihydroxy-3-methylanthraquinone on human gastric cancer SGC-7901 cells in vitro and in vivo.
Peganum
–Anticancer activities of harmine by inducing a pro-death autophagy and apoptosis in human gastric cancer cells.
–Harmine induces apoptosis and inhibits tumor cell proliferation, migration and invasion through down-regulation of cyclooxygenase-2 expression in gastric cancer.
–[Harmine induces apoptosis in human SGC-7901 cells].
Rabdosia
–Oridonin Suppresses Human Gastric Cancer Growth in Vitro and in Vivo via Inhibition of VEGF, Integrin β3, and PCNA.
–Oridonin induces growth inhibition and apoptosis in human gastric carcinoma cells by enhancement of p53 expression and function.
–Oridonin induces apoptosis through the mitochondrial pathway in human gastric cancer SGC-7901 cells.
–Downregulation of Cdk1 and cyclinB1 expression contributes to oridonin-induced cell cycle arrest at G2/M phase and growth inhibition in SGC-7901 gastric cancer cells.
Rosemary
–Sageone, a diterpene from Rosmarinus officinalis, synergizes with cisplatin cytotoxicity in SNU-1 human gastric cancer cells.
Solanum
–Purification, antitumor activity in vitro of steroidal glycoalkaloids from black nightshade (Solanum nigrum L.).
Withania
–Withaferin A inhibits the proliferation of gastric cancer cells by inducing G2/M cell cycle arrest and apoptosis.