An Gong Niu Huang Wan 安宫牛黄丸
Calm the Palace Pill with Bezoar
Tradition:
TCM
Source / Author:
Systemic Differentiation of Warm Pathogenic Disease, 1798
Herb Name | Latin | Amount |
|---|---|---|
Bezoar | 30 grams ea. | |
Cornu Rhinoceri | ||
Moschus moschiferus | ||
Dryobalanops aromatica | 7 1⁄2 grams ea. | |
Coptis chinensis | ||
Scutellaria baicalensis | ||
Gardenia jasminoides | ||
Curcuma aromatica | ||
Arsenic sulphide | 30 grams ea. | |
Margarita | 15 grams | |
Cinnabaris | 30 grams |
* Artificial (‘ren-gong’, man-made) Bezoar is often used in patent medicines
** Water Buffalo horn concentrate now replaces Rhinoceros horn in a dose of 60 grams
*** Synthetic Musk is typically used in place of genuine Musk in modern times.
Preparation:
Powder and form Honey pills each weighing 3 grams. Traditionally wrapped in Gold leaf.
Function:
Clears Heat and Toxin, clears Phlegm, open the Orifices of the Mind, calms the Mind and Spirit
Use:
The following conditions will manifest with High Fever, restlessness, irritability, a deep red tongue and a rapid pulse.
1. High Fever with Delirium, Irritability, Coma
2. Convulsions associated with High Fever
3. Acute Encephalitis
4. Acute Meningitis
5. Acute Hepatitis
6. Acute Pneumonia
7. CVA
8. Hepatic Coma
Dose:
One pill (3 grams) twice daily
Cautions:
1. Not used during Pregnancy.
2. Avoid in conditions without marked Heat.
3. Not used long-term due to Arsenic and Cinnabar content.
Modifications:
1. As noted above, sucbtiutes for Musk and Rhinoceros horn are used in modern times.
2. Cinnabar can be removed.
Similar Formulas:
This formula focuses on clearing Heat and Toxin. Its ability to opening the orifices (sense organs) and clearing Phlegm is secondary. Zhi Bao Dan has similar functions and uses, but is more focused on clearing Phlegm-Heat and opening the Orifices of the Brain.
These types of formulas have been very important in the treatment of severe Infection with High Fever. They are credited with saving many lives in the past.
Click the above Tabs for more information on this medicine
SAFETY:
–In vitro safety evaluation study of Angong Niuhuang Wan
NEUROPROTECTIVE:
–Realgar and cinnabar are essential components contributing to neuroprotection of Angong Niuhuang Wan with no hepatorenal toxicity in transient ischemic brain injury.
–Neuroprotective Effects and Hepatorenal Toxicity of Angong Niuhuang WanAgainst Ischemia-Reperfusion Brain Injury in Rats.
ISCHEMIC STROKE:
–Research Hotspots and Frontiers of Ischemic Stroke and Traditional Chinese Medicine: A Knowledge Mapping and Text Mining Analysis.
–Comprehensive immune modulation mechanisms of Angong Niuhuang Wan in ischemic stroke: Insights from mass cytometry analysis.
–Angong Niuhuang Wan inhibit ferroptosis on ischemic and hemorrhagic stroke by activating PPARgamma/AKT/GPX4 pathway.
–Angong Niuhuang Wan reduces hemorrhagic transformation and mortality in ischemic stroke rats with delayed thrombolysis: involvement of peroxynitrite-mediated MMP-9 activation.
–Exploring Active Compounds and Mechanisms of Angong Niuhuang Wan on Ischemic Stroke Based on Network Pharmacology and Molecular Docking.
CEREBROVASCULAR EDEMA:
–Angong Niuhuang Wan ameliorates LPS-induced cerebrovascular edema by inhibiting blood-brain barrier leakage and promoting the membrane expression of AQP4.
ACUTE LUNG INJURY:
–Angong niuhuang wan attenuates LPS-induced acute lung injury by inhibiting PIK3CG/p65/MMP9 signaling in mice based on proteomics.
PULMONARY FIBROSIS
–Qingkailing granule alleviates pulmonary fibrosis by inhibiting PI3K/AKT and SRC/STAT3 signaling pathways.
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