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Ruta, Rue

'Herb of Grace'
Sudab (Unani)
Sitav (Ayurveda)

Picture
Picture
Ortus Sanitatis, Meydenbach, 1491

Picture
Kohler's Medizinal Pflanzen, 1887

Botanical name:
Ruta graveolens

Parts used:
Herb; Seed

Temperature & Taste:
Warm (Cold in TCM), dry. Pungent, Bitter

Classifications:
2C INCIDERS.    2D ATTENUATERS OF CONGEALED BLOOD.    2I. ANTISPASMODIC.    2K. RESOLVENT.    2M. DRAWING.    2Z. CICATRIZING
3C. ALEXIPHARMIC.    3G. EMMENAGOGUE
4h. NEPHRITIC.    4i. UTERINE.    4k. ARTHRITIC

Uses:
1. Moves the Blood, Regulates Menstruation:
-promotes menstruation when delayed, suppressed or painful
-painful, irregular Menstruation; dark or clotted menstrual blood
-female obstructions from cold or shock.
-promotes
Labor, expel a Dead Child and Afterbirth.

2. Move the Blood, clears Stasis, Eases Pain:
-bruising, stagnant or congealed blood and for all Trauma with swelling and pain.
-can be used for Tumors, including Fibroids and Cysts of the Uterus
-a special function on the Cartilage, Ligaments and Tendons; used for Sprains, Tendonitis,
bone or joint pain

3. Clears Wind-Damp, Promotes Urine:
-promotes Urine in Edema or urinary obstruction
-the Oil anointed over the bladder region can promote urine 
-Arthritis, Sciatica, Gout and Rheumatism (decocted in Wine)


4. Calms the Liver, Stops Wind:
-Galen noted that Rue ‘extinguishes Wind’.
-Hypertension, Tension Headaches, Palpitations with Anxiety, Hysteria, Vertigo, Dizziness
-childhood Convulsions and Epilepsy. Has been used for Infantile Convulsions in modern TCM.
-degenerative conditions including Multiple Sclerosis, and for Bell’s Palsy.


5. Resists Poison:
-‘The seed taken in wine, is an antidote against all dangerous medicines or Deadly poisons’.
(Culpeper)
-‘If a man be anointed with the juice of Rue, the poison of Wolf’s Bane, Mushrooms, or Toadstools, the bitings of Serpents, stingings of Scorpions, Spiders, Bees, Hornets and Wasps will not hurt him’. (Gerard)
-‘It roots out the venom of the Plague and other Poisonous and Malignant diseases, and preserves from the same’.
-Rabies
-In modern TCM, it is regarded as Cold, and is used for Wind-Heat types of Fever and Virus, as well as the Bites of Snakes, Scorpions and Centipedes. (The seeds and leaf were used for this function, the seed being preferred)


6. Clears Phlegm, Resolves Swellings:
-Galen
noted Rue to ‘digest all thick viscous fluids’.
-‘he hath virtue of Purging, Dissolving, and Consuming’ (
A Boke of the Properties of Herbs called an Herball, 1560)
-various swellings including Scrofula, Ganglions and other phlegm-type swollen glands and Tumors. (internally and externally)


7. Clears Phlegm, Stops Cough:
-cough with thick white or clear phlegm; used for chest congestion, Bronchitis, and Asthma. (West, Ayurveda)


8. Benefits the Eyesight:
-traditionally said to ‘quicken the Sight’
(Gerard); used to benefit Eyesight since Pliny.
-burning, inflamed or aching eyeballs, as well as Headaches related to Eye strain.
-weak infusion of the leaves gives much benefit when used as a wash.


9. Used for Melancholy:
-long used for Mental Illness and Insanity;
-used in enema, it quickly eliminates Black Bile (Unani)
-‘A person who is Melancholic will be better when he eats Rue after a meal’
(Hildegard).

10. Warms and Strengthens the Kidneys:
-
Fear; promotes Bravery (Arab physicians)
-Traditionally said to be Aphrodisiac.
-Hernia (
School of Salerno)
-Leukorrhea


11. Kills Worms:
-used for Worms for which it was often boiled in Milk; some preferred the seed for this purpose.
-Dioscorides
recommended boiling in Olive oil and drinking for Worms

12. Externally:
-juice or Oil is applied to Warts and other skin growths.
-ointment, cataplasm or poultice formed by boiling the herb in Vinegar is applied
to Rheumatism, Gout, Sciatica
-juice is also dropped into the ears for Earache.
-as a wash for sore, red eyes, and various eye diseases; 1 drop
of the diluted essential oil was previously applied directly to the eye
-applied as a plaster with Barley for severe Eye pain (Dioscorides)
-oil or tincture is applied for Lethargy, Vertigo, Headache, Migraine
-oil was applied to spine in Fevers.
-good for Cold, Humid and Watery Tumors.
-decoction in wine is a good gargle for rotten Teeth and inflamed Gums.
-topically for Infection and Ulcers of the Skin, and for Eczema.
-with vinegar and Rose oil for itching (Unani)

-topically used for Cervical Cancer


DOSE:
In INFUSION or BRIEF DECOCTION: 2–6 grams, up to a maximum of 9 grams being taken daily (1–2 tablespoonful per cup of boiling water); Of the TINCTURE (1:5 in 45% alcohol): 1–3, or 4 mls, 2–3 times daily;
Of the
FLUID EXTRACT (1:1 in 45% alcohol): 5–15 drops;
Of the
ESSENTIAL OIL: 1–2 drops (up to 4 or 5 drops being taken traditionally), either well diluted, or taken on sugar;
Of the
POWDERED HERB: 100mg–2 grams, up to 3 grams. 100mg–1 gram promotes Menstruation. Half a teaspoonful every morning for 9 days in the treatment of Convulsions, Paralysis etc. Some said if 2 drams of powdered Rue was taken daily on an extended basis, it would achieve wondrous results;
Of the JUICE: 5mls., diluted. It is also used externally in pastes, poultices, plasters, washes, enemas, douches etc.

PREPARATION:
Sometimes Rue is toasted until browned. This lessens its pungent nature, increases its warming nature, and effect of restraining the Kidneys in Spermatorrhea or Premature Ejaculation. It is also milder, so is preferred for those with a delicate or weak constitution.

CORRECTIVES:
Aniseed (Unani)

SUBSTITUTES:
Oregano, Peppermint (Unani)

Main Combinations:
Calamus & Rue

Gynecology & Menstruation
1. Obstructions of the Uterus, Menstrual pain and cramping and to promote Birth, Rue with Rosemary, Savin, Lavender, Marjoram, Pennyroyal, Motherwort, Cyperus rotundus, Lovage root, Orange peel, Aniseed, Cinnamon (as in Uterine Elixir)
2. Promote Menstruation:
i. Rue and Pennyroyal decocted in Wine
ii. Rue with Yarrow, Camomile, Orange peel, Fennel seed (as in Uterine Powder)
iii. Rue with Camomile, Balm, Rosemary (Kroeber)
iv. and Chlorosis, Rue with Thyme, Centaury, Maidenhair, Oregano
v. Rue, Sage, Motherwort, Pennyroyal
vi. Rue with Black Cohosh
3. Suppressed or Obstructed Menstruation, Rue with Cinnamon, Myrrh, Savin, Celery seed, Asarum, Rhubarb, Saffron, Madder, Wormwood, Pennyroyal (as in Tincture for Suppressed Menstruation)
4. Pre-Menstrual Syndrome (PMS), Rue with Sage
5. Leukorrhea, Rue with Agnus Castus, Fennel, Cinnamon (as in Powder for Leukorrhea)
6. Infertility from Damp-Phlegm obstruction, Rue, Pennyroyal, Wormwood, Poke root,
7. Trichomonas vaginalis, Rue with Violet

Head and Nerves:
8. Headache, Rue with Fennel seed and Lovage (as in Potion for Headache of Galen)
9. Diseases of the Head (Epilepsy, Vertigo, Dizzyness etc):
i. Rue with Oregano, Balm, Marjoram, Rosemary, Betony, Sage, Clove, Nutmeg, Aniseed, Siler, Pyrethrum (as in Powder for Epilepsy of Philon)
ii. Rue with Peony, Calamus, Mistletoe, Betony, Sage, Marjoram, Calamint, Rue, Peony, Juniper, Rosemary (as in Cephalic Decoction)
iii. Rue with Amber, Savin, Frankincense, Cannabis seed, Stoechas (as in Cephalic Powder)
10. Cionvulsions:
i. Rue, Peony, Mistletoe
ii. Rue, Mistletoe, Motherwort, Pellitory of the Wall, Tansy (as a decoction) (Valuable Herbal Prescriptions, late 1800's)
11. Vertigo, Rue, Horehound, Pennyroyal; decoct until one-third has wasted. Strain, add Honey, and boil until thick. Take 1–2 spoonfuls each morning for 7 mornings.
12. Insomnia:
i. Rue with Camomile
ii. Rue with Lavender
13. Nightmares:
i. Rue with Balm
ii. Rue with Schisandra

Heart & Blood
14. Heart pain and Angina, Rue with Balm and Mother of Thyme (Schönmehl)
15. Hypertension:
i. Rue and Kelp
ii. Rue and Rosemary
16. Anemia, Rue with Calamus, Sarsaparilla, Elecampane, (Bischoff)

Infection
17. Preservative against infection:
i.
Rue with Walnut, Figs
ii.
Rue with Walnut, Figs, Juniper berry
iii.
Walnut, Fig, Rue, Salt, Honey Electuary of Nuts (Mithridate)
iv. Rue with Balm, Calendula, Angelica, Zedoary, unripe Walnuts, Citrons (as in Preservative Water)
18. To prevent Rabies once bitten, Rue with Vervain, Sage, Plantain, Wormwood, Mint, Balm, Betony, St. John's wort (as in Powder Against Rabies)
19. Gonorrhea:
i. Lettuce seed, Cannabis seed, Rue seed (as in Powder for Gonorrhea from Heat)
ii. Rue seed, Mint, Agnus Castus, Orris, Lettuce seed (as in Powder for Gonorrhea)
Lungs
20. Cough, difficulty Breathing, pains of the sides, early stages of Edema, Rue with Dill, Fennel seed
21. Cough:
i. Rue with Hyssop and Fig (Dioscorides)
ii. Rue with Horehound, Hyssop, Thyme, Pennyroyal, Aniseed (as in Decoction for Cold Coughs of Nicolas Myrepsus)
iii. 'dangerous cough', Rue with Sage and Cumin (The Physicians of Myddvai)

Gastrointestinal
22. Loss of appetite,
Rue with Sage and Wormwood
23. Indigestion, Stomach Pain, Abdominal fullness, Food Stagnation,
Rue, Cumin, Long Pepper (as in Lesser Cumin Composition of Galen)
24. Stomach pain:
i.
Rue with Camomile, Marjoram, Pennyroyal, Rosemary, Cumin, Aniseed, Fennel seed, Dill seed (as in Decoction for Stomach Pain)
ii. Rue with Cumin, Nigella, Caraway, Bitter Almond, Long Pepper, Marjoram, Wild Mint, Calamus, Bay berry (as in Electuary of Bayberries)
25. Hernia, Rue with Elecampane (School of Salerno)
26. Liver and Spleen obstruction, decoction Rue with Fennel root

Male disorders
27. Premature Ejaculation, use Unripe Rue, Toasted Rue, Poppy seed, Sesame seed (as in Pills of Hindi Mumsik of Unani)
28. Spermatorrhea, Premature Ejaculation, Rue with Angus Castus, Rose, Pomegranate, Lettuce, Licorice (as in Powder of Licorice of Unani)
29. To quench Lust, Rue with Sage and Rose (School of Salerno)
30. Swollen and inflamed Testicles:
i. from abstinence, Rue with Wormwood (Hildegard)
ii. Rue with Bay leaves (Dioscorides)

Other
31. Joint pain:
i. beat Raisin pulp with fresh Rue leaves and apply (The Secrets of Alexis, 1615)
ii. Rue with Ground Pine, Germander, Gentian (as in Powder Against Joint Pain)
32 Edema, Rue Water with Syrup of Two Roots (Herbarium Horstianum, 1630)
33. Incontinence:
i. Rue with Acorn, Frankincense, Myrrh, Calamus (as in Powder for Incontinence of Alexander Benedictus)
ii. Rue seed with Comfrey, Cyperus rotundus, Plantain, Horsetail, Agnus Castus, Frankincense (as in Wine for Incontinence)
34. Enuresis in children, Rue with St. John's wort, Camomile
35. Dribbling Urine, Rue with Saw Palmetto
36. Poor or failing Eyesight:
i. Rue is often combined with Fennel seed
ii. Rue Water, Eyebright Water (Herbarium Horstianum, 1630)
ii. Eyebright, Rue, Betony
iii. Eyebright, Rue, Betony, Rosemary, Elecampane, Fennel root, Chebulic Myrobalan, Rue seed, Lovage seed
37. Lameness, bathe in a decoction of Rue and Rosemary, or prepare an Oil for external use
38. Fistula in the corner of the Eye, decoct Rue, Agrimony and Celandine in Brandy; apply 3 times daily (Wirtzung)
39. Tinnitus, Rue with Marjoram, Stoechas, Wild Mint, Camomile as a tincture topically
40. Erysipelas, Shingles, Rue with Vinegar, White Lead and Ointment of Rose (Dioscorides)

Major Formula:
Decoction of Hyssop and Rue
Cephalic Decoction (Charras)
Decoction for Cold Coughs (Nicolas Myrepsus)
Decoction of Elecampane and Rue
Decoction for Chlorosis
Syrup of Betony (Bononiense)
Syrup of Mugwort (Augustana)
Electuary of Nuts (Mithridate)
Electuary of Dates (Diaphoenicum) (Mesue)
Electuary of Hyssop (Diahyssopus) (Nicholas)
Electuary of Bayberries (Electuarium de Baccis Lauri)
Lesser Cumin Composition of Galen
Confection of Eyebright (Confectio Humain) (Mesue)
Powder of Licorice (Unani)
Powder Against Rabies
Uterine Powder (Species Hysterica)
Foetid Pills Minor of Galen
Foetid Pills Major of Galen
Foetid Pills (Mesue)
Pills to Aggregate Greater (Mesue)
Oil for Lameness

Cautions:
1. Not used during Pregnancy or when Breastfeeding (it can dry up milk)
2. Not used in Uterine Bleeding
3. Not used in Yin deficiency (very drying)
4. Harmful to the Bladder and abdominal viscera. (Mahadevadeva, Unani)
5. Some people may experience Melancholy or sleep disorders with use of Rue.
6. Phototoxicity can occur with usage of Rue.

Main Preparations used:
Conserve, Extract, Distilled Water, Vinegar, Distilled Water, Infused Oil, Tincture of Rue

1. Conserve of Rue:
i. fresh leaves of Rue, White Sugar (equal parts). Beat. (Pharmacopoeia Sardoa, 1773)

2. Extract of Rue:
i. fresh Rue (1 lb.), Water (8 lbs.). Boil to half, express, strain. Evaporate slowly to the thickness of a pill-mass. .

3. Vinegar of Rue:
i. fresh leaves of Rue (1 part), Vinegar (10 parts). Macerate without heat for several days, express, filter. (Pharmacopee Usuelle, Louvain, 1821)

4. Distilled Water of Rue:
i. Rue, bruised (1 part), Water (4 parts). Distil two parts. (Dispensatorium medico pharmaceuticum Palatinatus, 1764)

5. Infused Oil of Rue:
i. Fresh Rue, Olive oil (equal parts). Digest 3 days, express (Dispensatorium Pharmaceuticum, 1777)

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'The leaves dried and burnt are used by the Hindus for the purpose of fumigating young children suffering from catarrh; they are also used fresh, bruised and mixed with arrack as an external remedy in the first stages of paralytic affections; dried and powdered they are prescribed in conjunction with aromatics in cases of dyspepsia; they are considered to be injurious to pregnant women; an opinion also entertained by Dioscorides. Rue was held in high estimation by the Greeks and Romans, and was a principal ingredient in the celebrated antidote of Mithridates. Pliny notices it in several parts of his Natural History, and calls it one of the best medicinal herbs.  Celsus says of Rue, " Urinam movet, sensus excitat, purgat, mollit." Hippocrates considered it to be resolvent and diuretic, and notices it in his chapter on female diseases. The Arabians class Rue among their attenuentia, vesicatoria and stimulantia. The author of the Makhzan-el-Adwiya describes three kinds—garden, wild, and mountain Rue, He considers it to be hot and dry in the third degree, to increase the mental powers, to act as a tonic and digestive, and to increase the urinary and menstrual excretions. He also states that it acts as an antaphrodisiac and causes abortion when given to pregnant women. The diseases in which it is recommended are so numerous that I must refer the reader to his article " Sudab." Early European practitioners considered Rue to be antispasmodic, stimulant and emmenagogue, and prescribed it in hysteria and flatulent colic. Boerhaave extols its virtues in promoting perspiration. In the Schola Salerni, the following lines occur :—
         "Ruta facit castuni ; dat lumen, et inherit astum.
          Cocta facit ruta, de pulicibus locatuta
."

Rue is the Herb Grace of old English writers, and is still much used as a domestic remedy. Alibert says of it, "Cetto plante a un grande action sur le systeme nervenx, et particulierement sur le systeme uterin. Beaucoup de femmes en prennent dans les menstrues laborieuses." The dose of the powdered leaves is from ten grains to a scruple or more, twice or thrice daily. Rue occupies a corner in most Bombay gardens; it grows freely, but does not generally flower.


Rue is an active irritant, whether applied externally or taken internally. It has been frequently used with success to procure abortion; sometimes it produces painful vomiting, always great prostration, confusion of mind, cloudy vision, feebleness and slowness of pulse, coldness of the extremities, and twitching of the limbs; in pregnant women the drug produces pain in the back, bearing down, and frequent micturition, followed by pains and abortion about ten days after the commencement of its administration. Oil of Rue has been observed to produce similar symptoms with increased frequency and diminished tension of the pulse; on the other hand, when an infusion of the dry leaves was used, the pulse fell from 80 to 69 in three hours.— (Van de Warker, Criminal Abortion, 1872.) (Vegetable Materia Medica of Western India, Dymock, 1885
1. GENERAL / REVIEW
–Genus Ruta: A natural source of high value products with biological and pharmacological properties.
–Identity and pharmacognosy of Ruta graveolens

2. ANTIBACTERIAL:
–Determination of antibacterial activity and metabolite profile of Ruta graveolens against Streptococcus mutans and Streptococcus sobrinus.
–Chemical composition and antimicrobial activity of the essential oils from four Ruta species growing in Algeria.
–Antimicrobial and cytotoxic activity of Ruta graveolens.

3. ANTI-FUNGAL:
–Algicidal and antifungal compounds from the roots of Ruta graveolens and synthesis of their analogs.
–Natural fungicides from Ruta graveolens L. leaves, including a new quinolone alkaloid.
–active against Colletotrichum, Fusarium, Botrytis, and especially Phomopsis species. (Tan et al., Planta Med, Feb 1999; Oliva et al., J Agric Food Chem, Feb 2003)

4. ANTI-INFLAMMATORY:
–Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats.
–Oral administration of alkaloid fraction from Ruta graveolens inhibits oxidative stress and inflammation in hypercholesterolemic rabbits.
–Anti-inflammatory effect of quinoline alkaloid skimmianine isolated from Ruta graveolens L.
–Protective effects of isolated polyphenolic and alkaloid fractions of Ruta graveolens L. on acute and chronic models of inflammation.
–Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats.
–Anti-inflammatory effect of Ruta graveolens L. in murine macrophage cells.
–Phytochemical Characterization, and Antioxidant and Antimicrobial Properties of Agitated Cultures of Three Rue Species: Ruta chalepensis, Ruta corsica, and Ruta graveolens.

5. ANTI-OXIDANT:
–Oral administration of alkaloid fraction from Ruta graveolens inhibits oxidative stress and inflammation in hypercholesterolemic rabbits.
–Methanolic extract of Ruta graveolens L. inhibits inflammation and oxidative stress in adjuvant induced model of arthritis in rats.
–Extraction of antioxidants from plants using ultrasonic methods and their antioxidant capacity.

6. ANTI–PYRETIC:
–Antinociceptive, anti-inflammatory and antipyretic activities of the leaf methanol extract of Ruta graveolens L. (Rutaceae) in mice and rats.

7. ANTI-HYPERTENSIVE:
–The cardiovascular effects of green beans (Phaseolus aureus), common rue (Ruta graveolens), and kelp (Laminaria japonica) in rats.
–Ruta Montana Evokes Antihypertensive Activity Through an Increase of Prostaglandins Release in L-NAME-Induced Hypertensive Rats.

8. ANTI-ULCER:
–Protective effect of hydro-alcoholic extract of Ruta graveolens Linn. leaves on indomethacin and pylorus ligation-induced gastric ulcer in rats.

9. ANTI-TUMOR:
–Anti-tumour activity of Ruta graveolens extract.

10. ANTI-CANCER:
–Therapeutic management of peritoneal ascitic sarcomatosis by Ruta graveolens: A study in experimental mice.
–Ruta graveolens extract induces DNA damage pathways and blocks Akt activation to inhibit cancer cell proliferation and survival.
T-CELL LEUKEMIA / LYMPHOMA
–Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens.
BREAST:
–Antiproliferative Effects of Various Furanoacridones Isolated from Ruta graveolens on Human Breast Cancer Cell Lines.
BRAIN CANCER / GLIOBLASTOMA
–Ruta graveolens L. induces death of glioblastoma cells and neural progenitors, but not of neurons, via ERK 1/2 and AKT activation.
MELANOMA:
–Evaluation of chemopreventive potentials of ethanolic extract of Ruta graveolens against A375 skin melanoma cells in vitro and induced skin cancer in mice in vivo.
–Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway.

11. ANTI-ASTHMATIC:
–Medicinal Plants for the Treatment of Asthma: A Traditional Persian Medicine Perspective.

12. HORMONAL EFFECT:
–"Not tonight zebrafish": the effects of Ruta graveolens on reproduction.

13. ANTI-ANDROGENIC:
–Antiandrogenic activity of Ruta graveolens L in male Albino rats with emphasis on sexual and aggressive behavior.

14. ANTI-FERTILITY EFFECT:
–"Not tonight zebrafish": the effects of Ruta graveolens on reproduction.
–New quinoline alkaloid from Ruta graveolens aerial parts and evaluation of the antifertility activity.
–Post-coital antifertility action of Ruta graveolens in female rats and hamsters.
–Antifertility principle of Ruta graveolens.

15. CONTRACEPTIVE EFFECT:
–Medicinal Plants Used in Iranian Traditional Medicine (ITM) as Contraceptive Agents.
–Immobilising effect of Ruta graveolens L. on human spermatozoa: coumarin compounds are involved.
–Acute Effects of Ruta graveolens L. on Sperm Parameters and DNA Integrity in Rats.
–Immobilization effect of Ruta graveolens L. on human sperm: a new hope for male contraception.
–Effect of Ruta graveolens and Cannabis sativa alcoholic extract on spermatogenesis in the adult wistar male rats.

16. ENHANCE LEARNING & MEMORY
–Ruta graveolens and rutin, as its major compound: investigating their effect on spatial memory and passive avoidance memory in rats.

17. ENHANCE NERVE GROWTH FACTOR:
–Enhancement of the nerve growth factor-mediated neurite outgrowth from PC12D cells by Chinese and Paraguayan medicinal plants.
–Rue markedly increases Nerve Growth Factor (NGF). (Biol. Pharm. Bull. July 1999)

18. NEUROPROTECTIVE / NEURORESTORATIVE
–Ruta graveolens as a potential source of neuroactive compounds to promote and restore neural functions

19. MULTIPLE SCLEROSIS:
–Efficacy and Tolerability of Phytomedicines in Multiple Sclerosis Patients: A Review.

20. ANTI-DIABETIC:
–Ethanol extracts of Herba Rutae increased glucose utilisation in muscle cells (137% increase). (van Huyssteen et al., Afr J Trad. Complement Altern Med., 2011)

21. SIGNIFICANTLY INCREASED BODY WEIGHT:
–Herba Ruta significantly increased body weight and total food intake, as well as a significant increase in protein efficiency following oral intake of the ether extract (500mg/ kg) to growing rats over a 3 week period. A marked increase in alkaline phosphatase was also noted. (Al-Okbi et al., Indian J Exp Biol, Jan 2002)

22. ANTI-TRYPANOSOMIASIS:
–Potential therapeutic use of herbal extracts in trypanosomiasis.

23. SCHISTOSOMIASIS
–In Vitro Schistosomicidal Activity of the Alkaloid-Rich Fraction from Ruta graveolens L. (Rutaceae) and Its Characterization by UPLC-QTOF-MS.

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