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Colocynth, Coloquintida

Bitter Apple
Hanzal (Unani)
Ortus Sanitatis, Meydenbach, 1491

Mesue, Opera de Medica, 1589
Della Materia Medicinale, Andrea Valuassori, 1562
Krauterbuch, Lonitzer, 1578

Botanische wandplaten, 1904–1914

(Köhler's Medizinal Pflanzen, 1897)

Above: Colocynth Fruit
(A Text-book of Botany and Pharmacognosy, Kraemer, 1909)

Right: Colocynth pulp
1, Part of a compressed cake of colocynth pulp. 2, Portions of the pulp free of seed, one piece showing seed cavities. 3, Seeds.
(Squibb's Atlas of the Official Drugs, Mansfield, 1919)










Left:
Container of Colocynth fruits as imported.
(A Text Book of Pharmacognosy,
Heber Wilkinson Youngken, 1921)
Colocynth fruit (Culcutta Unani College, Adam, 2019)

Botanical name:
Citrullus colocynthus (syn. Cucumis colocynthis)

Parts used:
Dried pulp of the fruit; Root

Temperature & Taste:
Hot, dry. Bitter, toxic

Uses:
1. Strongly Purges Water:
-hydrogogue cathartic; promotes passage of water via the bowels in full doses, but was otherwise used to potentiate more gentle purgative medicines in formula, which was by far the most common use.
-purges Bile and Phlegm; Purges Damp and Cold Phlegm from deep and remote parts, from the Brain, Nerves, Joints, Lungs
-Edema, Ascites; damp diseases of the Joints. Purges in all Damp and Watery diseases
-Fruit has been used in Jaundice

2. Clears Cold Phlegm, Stops Wheezing:
-Cough, Asthma with excess Cold Phlegm; also Pleurisy
-Dioscorides especially recommended it for Difficulty Breathing; Avicenna praised it similarly.

3. Drastically Promotes Menstruation:
-promotes Menstruation, which it does strongly.
-in ancient times a pessary to Terminate a Pregnancy.

4. Clears the Head, Guides Downward
-chronic and one-sided Headache, Epilepsy, Apoplexy, Vertigo, and dimness of Sight, but only in strong bodies.
-seeds were used to prevent the hair from greying

5. Emetic (taken in oil)
-classically used to promote Vomit

6. Externally:
-the fruit pulp is applied to Varicose Veins and Hemorrhoids.
-root paste is applied to Inflammations and Swellings
-cataplasm of the leaf is applied to Migraine and Neuralgia.
-Galen applied it topically to Sciatica; Avicenna used it in a plaster for Gout.


DOSE:
1. Usually only used in Powders, Pills and Troches.
2. Of its use in the form of Troches (see below) it was said 'and it is evident from long Experience that it is entirely free from Danger, when given seasonably and in a proper Dose'. The Troches were commonly used wherever Colocynth was ordered in a formula. (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
3. When infused or decocted it is very important to strain it through cloth to remove any irritant particles.
4. An extract prepared with Brandy purges less than the pulp in substance. (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
Of Colocynth in Pills and Powders: 500mg–2 grams (7 grains–1 scruple)

CORRECTIVES:
Tragacanth; Mastic; Almond oil (Unan)

SUBSTITUTES:
1. Aloe
2. Scammony; Ipomoea hederacea
3. Castor oil (Unani)

Main Combinations:
1. To Purge:
i. Troches of Colocynth (10 grains), Scammony prepared (6 grains), form a bolus with Electuary of Prunes. (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
ii. Colocynth with Sulphur, Long Pepper, Chebulic Myrobalan (Ayurveda)
2. To strongly promote Menstruation:
i. Troches of Colocynth (6 grains), washed Aloes (1 scruple), Saffron (8 grains), form a Bolus with Syrup of Wormwood. (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
3. Rheumatism, equal parts of Colocynth and Long Pepper are made into pills (Ayurveda)
4. Worms, mix Colocynth with Ox bile and apply to the Navel.
5. Toxic boils, equal parts of Colocynth fruit and Nux Vomica are mixed and applied.

Major Formulas
Foetid Pills (Mesue)
Lesser Pills of Cochia
Pills to Cleanse the Chest
Pills of Agaric (Avicenna)
Golden Pills (Nicholas)
Arabian Confect Purging Melancholy (Confectio Hamech) (Mesue)

Cautions:
1. Not used during pregnancy. It is abortifacient.
2. Strong and irritant, hurts the Stomach and Intestines.
3. Only used to strong bodies, should be corrected.

Main Preparations used:
Troches of Alhandal, Extract

1. Troches of Colocynth:
These are the preferred manner of using colocynth when prescribed internally:
  'Take Of the best Colocynth Pulp, cleared from its Seeds. q.s. cut it small with Scissors and rub it betwixt the Hands with q.s. of Oil pf sweet Almonds; then reduce it to a very fine or impalpable Powder in a Mortar, and make it up into small Troches with a Mucilage of Gum Tragacanth in Rose-Water. These being dried in the Shade, are to be powdered again as before, and made into Troches in the same Manner; and so repeating the Process a third Time let them be put by for Use. The Dose is from gr. vj to half a dram.' (A Treatise on Foreign Drugs, Geoffroy and Thicknesse, 1749)
History
'Indian colocynth is common in Western India, and ripens in the cold season. The fresh fruit is brought for sale to Bombay by the herbalists; it is also collected in the neighbourhood of Poona for the preparation of the compound extract at the Government Botanical Gardens near that town.

Sanskrit writers describe the fruit as bitter, acrid, cathartic and useful in biliousness, constipation, fever and worms. They also mention the root as a useful cathartic in jaundice, ascites, enlargements of the abdominal viscera, urinary diseases, rheumatism, &c. Sarangadhara gives a receipt for a compound pill which contains Mercury 1 part, Colocynth pulp, Sulphur, Cardamoms, Long Pepper, Chebulic myrobalans, and Pellitory root of each 4 parts. The Sanskrit name of Colocynth is Indravaruni. In the Concan the fruit and root, with or without nux vomica, is rubbed into a paste with water and applied to boils and pimples. In rheumatism equal parts of the root and long pepper are given in pill. A paste of the root is applied to the enlarged abdomen of children.
Mahometan writers call it Hanzal, and discuss its properties at great length. They consider it to be a very drastic purgative, removing phlegm from all parts of the system, and direct the fruit, leaves and root to be used. The drug is prescribed as with us, when the bowels are obstinately costive from disease or lesion of the nervous centres, also in dropsy, jaundice, colic, worms, elephantiasis, &c. Its irritant action upon the uterus is noticed, and fumigation with it is said to be of use for bringing on the menstrual flow. The author of the Makhzan describes a curious method of administration. A small hole is made at one end of the fruit and pepper-corns are introduced, the hole is then closed, the fruit enveloped in a coating of clay and buried in the hot ashes near the fire-place for some days; the pepper is then removed and used as a carminative aperient. A similar preparation is made with rhubarb root instead of pepper. The same author tells us that the seeds are purgative, and mentions their use for preserving the hair from turning grey. Colocynth was familiar to the Greeks and Romans. (Vegetable Materia Medica of Western India, Dymock, 1885)